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Stroke in central nervous system infections.

Francisco Javier Carod-Artal1

  • 1Department of Neurology, Sarah Hospital, The Sarah network of Rehabilitation Hospitals, Brasilia DF, Brazil.

Annals of Indian Academy of Neurology
|June 20, 2022
PubMed
Summary

Infectious diseases are a significant cause of stroke, particularly in tropical regions. Consider infections like HIV, malaria, and neurocysticercosis in stroke diagnosis.

Keywords:
AIDSinfectious diseasesneurocysticercosisstroketuberculosis

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Public Health

Background:

  • Stroke etiology varies globally, with infections being a notable cause in developing and tropical countries.
  • Infectious agents can directly impact the cerebrovasculature or trigger systemic responses leading to stroke.

Purpose of the Study:

  • To comprehensively review infectious diseases associated with stroke.
  • To highlight the importance of considering infections in stroke differential diagnoses.

Main Methods:

  • Literature review of infectious diseases linked to cerebrovascular events.
  • Analysis of pathogenic mechanisms and clinical presentations.

Main Results:

  • Human Immunodeficiency Virus (HIV) is linked to stroke through vasculopathy, vasculitis, and opportunistic infections.
  • Viral infections (e.g., Japanese encephalitis, dengue) and parasitic diseases (e.g., cerebral malaria, neurocysticercosis) are significant stroke causes.
  • Bacterial infections (tuberculous meningitis, Leptospira) and fungal infections can lead to vasculitis, aneurysms, and stroke.

Conclusions:

  • Infectious and tropical diseases are critical considerations in the differential diagnosis of stroke.
  • Early recognition and management of infections can prevent or mitigate stroke events.