Related Experiment Video

Updated: Sep 7, 2025

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
08:56

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

Published on: November 30, 2022

2.9K

Isoindolin-1-ones Fused to Barbiturates: From Design and Molecular Docking to Synthesis and Urease Inhibitory

Houman Kazemzadeh1, Elham Hamidian1, Faezeh Sadat Hosseini1

  • 1Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran 1416634793, Iran.

ACS Omega
|June 20, 2022
PubMed

Insights

Researchers developed novel isoindolin-1-one compounds to inhibit urease, an enzyme crucial for Helicobacter pylori survival. Compound 5b demonstrated potent urease inhibition, offering a promising strategy against H. pylori-related diseases.

Area of Science:

  • Medicinal Chemistry
  • Enzyme Inhibition
  • Green Chemistry

Background:

  • Helicobacter pylori infections cause significant gastric issues, including ulcers and cancer.
  • Urease enzyme is essential for H. pylori survival and virulence.
  • Developing effective urease inhibitors is a key therapeutic strategy.

Purpose of the Study:

  • To design and synthesize novel isoindolin-1-one derivatives.
  • To evaluate their in vitro urease inhibitory activity.
  • To investigate their potential as anti-H. pylori agents.

Main Methods:

  • Two-step synthesis utilizing green solvents (ethanol, water) and microwave irradiation.
  • In vitro urease inhibition assays comparing synthesized compounds to thiourea.
  • Molecular docking studies to elucidate binding interactions with Jack bean urease.

Main Results:

  • All synthesized compounds exhibited higher urease inhibitory activity than thiourea.
  • Compound 5b showed the most potent inhibition with an IC50 of 0.82 ± 0.03 μM.
  • Molecular docking results correlated well with in vitro findings, supporting compound efficacy.

Conclusions:

  • Novel isoindolin-1-one derivatives are effective urease inhibitors.
  • Compound 5b represents a highly promising lead for developing new treatments against H. pylori.
  • The employed green chemistry approach offers an efficient and sustainable synthesis route.

More Related Videos

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

6.8K
A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones07:30

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

Published on: January 21, 2020

8.2K

Related Concept Videos

Sedatives and Hypnotics Drugs: Barbiturates01:20

Sedatives and Hypnotics Drugs: Barbiturates

Sedatives and hypnotics encompass a drug class that acts on the central nervous system (CNS) to alleviate anxiety, promote relaxation and induce sleep.These drugs function by amplifying the actions of the neurotransmitter γ-aminobutyric acid (GABA), resulting in reduced neuronal activity. Barbiturates, a subset of sedatives and hypnotics first synthesized in the late 1800s, are categorized into ultra-short, short, intermediate, and long-acting groups based on their duration of effect. A...
459
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship01:29

Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship

Indirect-acting cholinergic agonists are agents that interact with the acetylcholinesterase enzyme in the synaptic cleft, preventing the breakdown of acetylcholine into choline and acetate. Consequently, the concentration of acetylcholine in the synaptic cleft increases. These agonists can be classified into reversible and irreversible inhibitors based on their duration of action.
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
643
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH301:11

ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3

All ortho–para directors, excluding halogens, are activating groups. These groups donate electrons to the ring, making the ring carbons electron-rich. Consequently, the reactivity of the aromatic ring towards electrophilic substitution increases. For instance, the nitration of anisole is about 10,000 times faster than the nitration of benzene. The electron-donating effect of the methoxy group in anisole activates the ortho and para positions on the ring and stabilizes the corresponding...
6.3K