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Association between chronic kidney disease and mortality in patients with a confirmed COVID-19 diagnosis

Jacqueline Betsabe Puicón-Suárez1, Sandra Zeña-Ñañez2, Virgilio E Failoc-Rojas3,4

  • 1Sociedad Científica de Estudiantes de Medicina, SOCIEM-UNPRG, Universidad Nacional Pedro Ruiz Gallo, Lambayeque, Perú.

Peerj
|June 20, 2022
PubMed

Insights

Chronic kidney disease (CKD) significantly increases mortality risk for patients diagnosed with coronavirus disease 2019 (COVID-19). This risk is further elevated when CKD is combined with diabetes mellitus and hypertension.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Epidemiology

Background:

  • Chronic kidney disease (CKD) is a global health concern.
  • Coronavirus disease 2019 (COVID-19) has emerged as a significant pandemic.
  • Understanding the interplay between CKD and COVID-19 outcomes is crucial for patient management.

Purpose of the Study:

  • To investigate the association between chronic kidney disease (CKD) and mortality in individuals diagnosed with coronavirus disease 2019 (COVID-19).

Main Methods:

  • Cross-sectional secondary baseline study.
  • Analysis of 243,065 patients diagnosed with COVID-19 between May and December 2020.
  • Statistical analysis included Chi-square tests and Poisson regression with robust variances using Stata 16.0.

Main Results:

  • Patients with COVID-19 and CKD exhibited a 1.42 times higher prevalence of mortality compared to those without CKD.
  • The highest mortality probability was observed in patients with CKD comorbid with diabetes mellitus and hypertension.
  • Comorbidities significantly amplified the mortality risk in COVID-19 patients with CKD.

Conclusions:

  • Chronic kidney disease (CKD) is strongly associated with increased mortality rates in COVID-19 patients.
  • The combination of CKD, diabetes mellitus, and arterial hypertension presents a significantly higher mortality risk.
  • Identifying and managing CKD in COVID-19 patients, especially those with diabetes and hypertension, is critical for improving survival rates.
Abstract

Keywords:
COVID-19Chronic kidney diseaseMexicoMortality

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