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Body mass index and postoperative mortality in patients undergoing coronary artery bypass graft surgery plus valve

Chun Dai1,2, Hongbo Xu1,2, Tianshu Chu3

  • 1The Lu'an Hospital Affiliated to Anhui Medical University, Lu'an, Anhui, China.

Peerj
|June 20, 2022
PubMed

Insights

Higher body mass index (BMI) increases postoperative mortality risk in patients undergoing coronary artery bypass graft (CABG) surgery and valve replacement. This study reveals a non-linear relationship, with risks elevated above a BMI of 25 kg/m².

Area of Science:

  • Cardiovascular Surgery
  • Obesity Research
  • Patient Outcomes

Background:

  • The association between body mass index (BMI) and outcomes following complex cardiac procedures like coronary artery bypass graft (CABG) surgery and valve replacement remains unclear.
  • Investigating BMI's impact is crucial for risk stratification and patient management in these high-risk surgical populations.

Purpose of the Study:

  • To examine the relationship between body mass index (BMI) and postoperative mortality in patients undergoing simultaneous CABG and valve replacement surgery.
  • To identify potential BMI thresholds associated with increased mortality risk in this patient cohort.

Main Methods:

  • Retrospective analysis of 1976 patients undergoing CABG surgery, including 202 who also had valve replacement, between January 2017 and April 2021.
  • Utilized smooth curve fitting and multiple logistic regression to assess the association between BMI and postoperative mortality.

Main Results:

  • A non-linear relationship was observed between BMI and postoperative mortality, characterized by a two-stage change and a breakpoint.
  • Postoperative mortality rates were higher in patients with a BMI exceeding 25 kg/m² compared to those with a BMI between 18 and 25 kg/m².

Conclusions:

  • A significant non-linear association exists between BMI and postoperative mortality in patients undergoing combined CABG and valve replacement surgery, even after adjusting for confounders.
  • Further research is warranted to elucidate the causal mechanisms underlying this relationship and its clinical implications.
Abstract

Keywords:
BMICardiac diseaseCoronary artery bypass graftMortalityValve replacement

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