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Gastric Neuroendocrine Tumor Treatment and Survival Outcome Depends on Facility Type

Rebecca M Platoff1, Johanna Lou1, Kathryn Bush2

  • 1Department of Surgery, Cooper University Hospital, Camden, NJ, USA.

The American Surgeon
|June 20, 2022
PubMed
Abstract

Insights

Patients with gastric neuroendocrine tumors (gNETs) treated at academic centers showed improved survival. Academic programs offered better outcomes for gNET treatment, especially with surgery or chemotherapy.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Health Services Research

Background:

  • Gastric neuroendocrine tumors (gNETs) are rare malignancies.
  • Surgical intervention may enhance survival for gNET patients.
  • The impact of treatment facility type on gNET outcomes is not well-established.

Purpose of the Study:

  • To investigate the association between healthcare facility type and treatment patterns for gastric neuroendocrine tumors.
  • To evaluate the effect of facility type on overall survival in patients with gNETs.

Main Methods:

  • Utilized the National Cancer Database (NCDB) to identify patients diagnosed with gNET between 2004 and 2016.
  • Stratified patients based on facility type: Academic/Research Program (ARP), Community Cancer Program (CCP), Comprehensive Community Cancer Program (CCCP), and Integrated Network Cancer Program (INCP).
  • Compared overall survival and clinical/demographic characteristics, employing propensity score matching for robust analysis.

Main Results:

  • Patients treated at academic programs experienced significantly longer median survival (137.3 months) compared to other facility types (88.0-100.2 months; P < .0001).
  • Academic centers demonstrated higher rates of surgical intervention (64.2%) compared to CCP, CCCP, and INCP (51.4%-59.1%; P < .0001).
  • Survival benefits associated with academic centers persisted after propensity matching, particularly for patients receiving surgery (P < .0001) and chemotherapy (P = .04).

Conclusions:

  • Treatment at an academic hospital is associated with improved median survival for patients with gastric neuroendocrine tumors.
  • Academic medical centers may offer superior outcomes for gNET management compared to community-based centers.
  • The findings suggest a potential benefit for patients seeking gNET treatment at specialized academic facilities.

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