Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

61
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
61
Anorexia Nervosa01:28

Anorexia Nervosa

184
Anorexia nervosa is a complex and severe eating disorder characterized by an intense fear of weight gain, an unrelenting pursuit of thinness, and a distorted body image. It often leads to dangerously low body weight relative to an individual's age and height. This disorder is marked by significant physical and psychological consequences, making it one of the most life-threatening psychiatric illnesses.
Symptoms and Physical Effects
Individuals with anorexia nervosa commonly exhibit extreme...
184
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

110
Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
110
Obesity01:24

Obesity

609
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
609
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

664
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
664
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

12.2K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
12.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction: Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion.

The Journal of experimental medicine·2026
Same author

From local pilots to national policy: key issues and challenges in implementing nationwide HPV vaccination in China.

The Lancet regional health. Western Pacific·2026
Same author

Spatially and temporally comparative proteomics provide insights into dynamic response patterns to PEDV infection.

Communications biology·2026
Same author

PARKIN overexpression confers cardioprotection via suppressing the mtDNA-cGAS-STING axis in myocardial ischemia/reperfusion injury.

Basic research in cardiology·2026
Same author

Case Report: PTCH1 splice-site mutation and sonidegib treatment in Gorlin-Goltz syndrome: clinical insights from a family case study.

Frontiers in medicine·2026
Same author

Flavor enhancement of corn oil through the solid-state complex-enzyme hydrolysis: Process optimization and mechanistic insights.

Food chemistry·2026

Related Experiment Video

Updated: Sep 7, 2025

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

6.0K

Nonobese Male Patients with Alzheimer's Disease Are Vulnerable to Decrease in Plasma Leptin.

Jing Tian1, Tienju Wang1, Kun Jia1

  • 1Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, USA.

Journal of Alzheimer'S Disease : JAD
|June 20, 2022
PubMed
Summary

Leptin levels are lower in males with Alzheimer's disease (AD), suggesting metabolic dysfunction contributes to AD in some populations. This hormone may not reflect disease severity but warrants further study in nonobese AD patients.

Keywords:
Alzheimer’s diseaseblood biomarkermetabolismplasma leptinsex

More Related Videos

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

16.7K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.1K

Related Experiment Videos

Last Updated: Sep 7, 2025

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

6.0K
Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
05:53

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty

Published on: July 24, 2013

16.7K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

15.1K

Area of Science:

  • Neuroscience
  • Metabolic research
  • Endocrinology

Background:

  • Metabolic dysfunction is linked to cognitive deficits in Alzheimer's disease (AD).
  • Leptin, an anti-obesity hormone, influences energy homeostasis and memory.
  • Previous studies on leptin's role in AD have yielded inconsistent clinical results.

Purpose of the Study:

  • To investigate plasma leptin changes in AD patients compared to cognitively unimpaired (CU) individuals.
  • To examine the correlation between sex-stratified leptin levels and cognitive performance, AD biomarkers, and metabolic status.

Main Methods:

  • Analysis of plasma leptin, AD biomarkers, and metabolic profiles in nonobese AD patients and CU controls.
  • Sex-stratified statistical analysis to determine correlations.

Main Results:

  • Male AD patients showed decreased plasma leptin compared to male CU counterparts; females did not.
  • Plasma leptin did not correlate with cognitive performance or AD biomarkers in either sex.
  • Females, but not males, showed associations between plasma leptin and metabolic parameters (BMI, HDL-C, cholesterol ratios, triglycerides).

Conclusions:

  • Leptin deficiency is associated with nonobese male AD patients, indicating systemic dysmetabolism in AD pathogenesis.
  • Plasma leptin may have limited utility in reflecting AD severity or progression.
  • Further research into leptin regulation in nonobese AD patients is needed to understand sex-related disparities in AD.