Related Experiment Video
Updated: Sep 7, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses
Xuan Yang1,2, Rebekah J Dickmander2,3,4,5, Armin Bayati6
1Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Abstract:
Inhibition of the protein kinase CSNK2 with any of 30 specific and selective inhibitors representing different chemotypes, blocked replication of pathogenic human, bat, and murine β-coronaviruses. The potency of in-cell CSNK2A target engagement across the set of inhibitors correlated with antiviral activity and genetic knockdown confirmed the essential role of the CSNK2 holoenzyme in β-coronavirus replication. Spike protein endocytosis was blocked by CSNK2A inhibition, indicating that antiviral activity was due in part to a suppression of viral entry. CSNK2A inhibition may be a viable target for the development of anti-SARS-like β-coronavirus drugs.
Related Concept Videos
Inhibition of Cdk Activity
cAMP-dependent Protein Kinase Pathways
The JAK-STAT Signaling Pathway
Single Nucleotide Polymorphisms-SNPs

