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Red cell distribution width, a predictive factor in immunocompromised patients with COVID-19: A comparison

Minoosh Moghimi1, Manijeh Jozpanahi2, Kasra Khodadadi3

  • 1Department of Internal Medicine, Zanjan University of Medical Sciences, Zanjan. mmoghimi2000@yahoo.com.

European Journal of Translational Myology
|June 20, 2022
PubMed

Insights

Lactate dehydrogenase (LDH) was the sole predictor of death in COVID-19 patients. Active cancer patients showed higher red cell distribution width (RDW), indicating more severe disease.

Area of Science:

  • Oncology
  • Nephrology
  • Infectious Diseases

Background:

  • COVID-19 presents unique challenges for immunocompromised patients, including those with cancer or kidney transplants.
  • Understanding disease outcomes in these vulnerable populations is crucial for effective management.

Purpose of the Study:

  • To compare COVID-19 outcomes in cancer and kidney transplant patients.
  • To identify predictors of mortality and ICU admission in these cohorts.

Main Methods:

  • Single-center, historical cohort study of 1135 COVID-19 patients.
  • Patients with cancer (active and non-active) and kidney transplants were analyzed.
  • Disease outcomes, including mortality and ICU admission, were compared between subgroups.

Main Results:

  • Lactate dehydrogenase (LDH) was the only significant predictor of death.
  • Red cell distribution width (RDW) was significantly higher in active cancer patients compared to kidney transplant patients.
  • Female sex and low oxygen saturation (SpO2) increased the likelihood of ICU admission.
  • No significant difference in mortality was observed between active and non-active cancer groups.

Conclusions:

  • Active cancer patients generally experience more severe and complicated COVID-19.
  • RDW may serve as a potential predictive marker for disease severity in cancer patients with COVID-19.
  • LDH is a key prognostic indicator for mortality in this patient population.

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