Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fast Fourier Transform01:10

Fast Fourier Transform

459
The Fast Fourier Transform (FFT) is a computational algorithm designed to compute the Discrete Fourier Transform (DFT) efficiently. By breaking down the calculations into smaller, manageable sections, the FFT significantly reduces the computational complexity involved. Direct computation of an N-point DFT requires N2 complex multiplications, whereas the FFT algorithm needs only (N/2)log⁡2N multiplications, offering a much faster performance.
The computational efficiency of the FFT becomes...
459
Fast Decoupled and DC Powerflow01:24

Fast Decoupled and DC Powerflow

275
The fast decoupled power flow method addresses contingencies in power system operations, such as generator outages or transmission line failures. This method provides quick power flow solutions, essential for real-time system adjustments. Fast decoupled power flow algorithms simplify the Jacobian matrix by neglecting certain elements, leading to two sets of decoupled equations:
275
Production Efficiency01:01

Production Efficiency

17.0K
Net production efficiency (NPE) is the efficiency at which organisms assimilate energy into biomass for the next trophic level. Due to low metabolic rates and less energy spent on thermoregulatory processes, the NPE of ectotherms (cold-blooded animals) is 10 times higher than endotherms (warm-blooded animals).
17.0K
Factors Influencing the Rate of Chemical Reactions01:22

Factors Influencing the Rate of Chemical Reactions

5.5K
A variety of factors influence the rate of chemical reactions. For a chemical reaction to happen, atoms must collide with enough energy to overcome the repulsion between their electrons. This energy is called activation energy. Factors influencing the rate of reaction either lower the activation energy or increase the likelihood of a successful collision.
Concentration and Pressure:
The more particles present within a given space, the more likely those particles are to bump into one another....
5.5K
Gene Evolution - Fast or Slow?02:05

Gene Evolution - Fast or Slow?

3.1K
3.1K
Column Efficiency: Rate Theory01:12

Column Efficiency: Rate Theory

528
The rate theory of chromatography provides quantitative insight into the shapes and widths of elution bands. These bands are based on the random-walk mechanism governing molecular migration within a column. The Gaussian profile of chromatographic bands arises from the cumulative effect of random molecular motions as they progress through the column.
During elution, a solute molecule experiences numerous transitions between stationary and mobile phases, exhibiting irregular residence times in...
528

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From roadmap to a sustainable end-to-end individualized therapy pathway.

Therapeutic advances in rare disease·2025
Same author

Clinical characterization of Collagen XII-related disease caused by biallelic COL12A1 variants.

Annals of clinical and translational neurology·2025
Same author

Response to Grosse et al.

American journal of human genetics·2023
Same author

Genomic sequencing has a high diagnostic yield in children with congenital anomalies of the heart and urinary system.

Frontiers in pediatrics·2023
Same author

Breaking Barriers to Rapid Whole Genome Sequencing in Pediatrics: Michigan's Project Baby Deer.

Children (Basel, Switzerland)·2023
Same author

A genome sequencing system for universal newborn screening, diagnosis, and precision medicine for severe genetic diseases.

American journal of human genetics·2022

Related Experiment Video

Updated: Sep 7, 2025

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
08:48

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Published on: November 22, 2019

7.7K

Better and faster is cheaper.

Erica F Sanford Kobayashi1,2, David P Dimmock2

  • 1Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Human Mutation
|June 20, 2022
PubMed
Summary

Rapid genomic sequencing now achieves molecular diagnosis in 8 hours, improving patient care and cutting healthcare costs. Faster results from whole genome and whole exome sequencing significantly impact clinical decisions and reduce overall expenses.

Keywords:
rapid whole-exome sequencingrapid whole-genome sequencingultra-rapid whole genome sequencing

More Related Videos

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
10:26

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection

Published on: June 13, 2017

8.9K
FIM Imaging and FIMtrack: Two New Tools Allowing High-throughput and Cost Effective Locomotion Analysis
10:02

FIM Imaging and FIMtrack: Two New Tools Allowing High-throughput and Cost Effective Locomotion Analysis

Published on: December 24, 2014

11.8K

Related Experiment Videos

Last Updated: Sep 7, 2025

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy
08:48

Low-cost Custom Fabrication and Mode-locked Operation of an All-normal-dispersion Femtosecond Fiber Laser for Multiphoton Microscopy

Published on: November 22, 2019

7.7K
Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection
10:26

Rewiring Neuronal Circuits: A New Method for Fast Neurite Extension and Functional Neuronal Connection

Published on: June 13, 2017

8.9K
FIM Imaging and FIMtrack: Two New Tools Allowing High-throughput and Cost Effective Locomotion Analysis
10:02

FIM Imaging and FIMtrack: Two New Tools Allowing High-throughput and Cost Effective Locomotion Analysis

Published on: December 24, 2014

11.8K

Area of Science:

  • Genomic Medicine
  • Molecular Diagnostics
  • Health Services Research

Background:

  • Genomic sequencing technology is advancing rapidly, enabling faster molecular diagnoses.
  • Evidence suggests quicker diagnostic results positively impact patient care and reduce healthcare expenditures.
  • The efficiency of genomic sequencing is crucial for timely clinical decision-making.

Purpose of the Study:

  • To review the diagnostic and clinical utility of rapid whole genome sequencing (rWGS) and rapid whole exome sequencing (rWXS).
  • To examine the associated reduction in healthcare costs linked to rapid genomic sequencing.
  • To analyze the relationship between time-to-diagnosis and clinical outcomes/cost savings.

Main Methods:

  • Literature review of studies on rapid whole genome and whole exome sequencing.
  • Analysis of diagnostic yield and clinical utility data.
  • Assessment of economic impact and healthcare cost reduction.

Main Results:

  • A record time to molecular diagnosis of 8 hours has been achieved.
  • Rapid genomic sequencing demonstrates significant diagnostic and clinical utility.
  • Faster turnaround times correlate with reduced healthcare costs.

Conclusions:

  • Rapid whole genome and whole exome sequencing are valuable tools for timely molecular diagnosis.
  • Accelerated genomic testing leads to improved patient care and significant healthcare cost savings.
  • Optimizing time-to-diagnosis is critical for maximizing the benefits of genomic sequencing.