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Menstrual Cycle Parameters Are Not Significantly Different After COVID-19 Vaccination.
Thomas P Bouchard1, Mary Schneider2, Madeline Schmidt2
1Department of Family Medicine, University of Calgary, Calgary, Alberta, Canada.
Journal of Women'S Health (2002)
|June 20, 2022
Summary
COVID-19 vaccines did not significantly alter key menstrual cycle parameters like cycle length or ovulation timing. Objective data showed no statistical changes, despite some women reporting perceived cycle alterations.
Area of Science:
- Reproductive Health
- Immunology
- Public Health
Background:
- Previous research suggested potential minor menstrual cycle changes post-COVID-19 vaccination.
- A need exists for detailed, objective analyses to confirm or refute these observations, minimizing recall bias.
Purpose of the Study:
- To prospectively evaluate the impact of COVID-19 vaccination on specific menstrual cycle parameters.
- To compare objective menstrual cycle data before, during, and after vaccination.
Main Methods:
- A pretest-post-test quasi-experimental design using an anonymous online survey.
- Prospective daily monitoring of menstrual cycle parameters (bleeding, hormone levels, cervical mucus) by participants.
- Analysis of 588 menstrual cycles (227 pre-vaccine, 145 vaccine, 216 post-vaccine) from 76 women.
Main Results:
- While 22% of women reported subjective menstrual cycle changes, objective analysis revealed no statistically significant differences in cycle length, menses duration, ovulation day, or luteal phase length.
- No significant variations were observed in menstrual cycle parameters across pre-vaccine, vaccine, and post-vaccine phases.
Conclusions:
- COVID-19 vaccination was not associated with statistically significant alterations in objective menstrual cycle parameters.
- Subjective perceptions of menstrual cycle changes should be critically evaluated against objective data to mitigate confirmation bias.
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