Internal flow field analysis of heterogeneous porous scaffold for bone tissue engineering

The internal pore structure of the porous scaffold for bone tissue engineering and the pressure and velocity distributions of its flow field affect the attachment, proliferation and differentiation of osteoblasts. The permeability of the porous scaffold determines its ability to transport cellular nutrients and metabolites. Therefore, studying the fluid flow characteristics of the porous scaffold plays a vital role in its biological applications. Heterogeneous porous scaffolds (HPS) with irregular internal pore structure have more bionic characteristics of natural structure than uniform porous scaffolds with regular internal pore structure. In order to comprehensively grasp the biological properties of HPS, this article designed HPS with different porosities based on the Voronoi generation method and random theory, and then used computational fluid dynamics (CFD)software to conduct fluid flow simulations. The velocity and pressure distribution rules of the internal flow field of HPS with different porosities were obtained by CFD simulation analysis, and the relationship between the porosity and the distribution rules was studied. Furthermore, the permeabilities of HPS with different porosities were calculated based on Darcy's law, and the influence rule of porosity on the permeability was obtained.