Thyroid hormone decreasing after mechanical thrombectomy for cerebral infarction

Area of Science:

• Endocrinology
• Neurology
• Radiology

Background:

• Mechanical thrombectomy (MT) is a key treatment for large vessel occlusion in cerebral infarction.
• Iodine contrast agents used in MT can impact thyroid hormone levels via the Wolff-Chaikoff effect.
• Low triiodothyronine (T3) syndrome is linked to poor prognosis in cerebral infarction patients.

Purpose of the Study:

• To investigate acute-phase changes in thyroid hormone levels following MT.
• To determine the influence of iodine contrast agents on thyroid hormones after MT.

Main Methods:

• A single-center, prospective, single-arm trial.
• Measurement of thyroid stimulating hormone (TSH), free T3 (FT3), and free T4 (FT4) on admission and 24 hours post-MT.
• Analysis of 31 patients undergoing MT for cerebral infarction.

Main Results:

• Significant decreases in TSH and FT3 levels were observed 24 hours after MT (P < 0.001).
• A correlation was found between the decrease in FT3 levels and the amount of iodine contrast agent used per body surface area (r = 0.43, P = 0.019).
• No significant correlation was detected for TSH or FT4 with contrast agent volume.

Conclusions:

• TSH and FT3 levels decrease in the acute phase after mechanical thrombectomy.
• The reduction in FT3 levels is associated with the volume of iodine contrast agent administered during MT.