Maternal PM_2.5 exposure during gestation and offspring neurodevelopment: Findings from a prospective birth cohort...

Emerging data have suggested the potential role of prenatal PM_2.5 exposure as a neurotoxin for offspring. However, the existing results are equivocal, and no study has examined the effects of complex chemical constituents of the particular matter on offspring neurodevelopment. Therefore, in a prospective birth cohort study conducted in Jiangsu, China, we aimed to investigate the association between prenatal exposure to PM_2.5 and the neurodevelopment in infants, and further assess the effects of specific chemical constituents of PM_2.5. A total of 1531 children who had available data on daily prenatal PM_2.5 exposure and completed assessment on neurodevelopment at 1 year old were enrolled. We used the high-performance machine-learning model to estimate daily PM_2.5 exposure concentrations at 1 km × 1 km spatial resolution. The combined geospatial-statistical model was applied to evaluate average concentrations of six chemical constituents [organic matter (OM), black carbon (BC), sulfate (SO₄^2-), nitrate (NO₃^-), ammonium (NH₄⁺), and soil dust (Dust)]. The neurodevelopment of children was assessed using Bayley-III Screening Test. After adjusting for confounding factors, the risk of non-optimal gross motor development increased by 31 % for every 10 μg/m³ increase in average PM_2.5 exposure during gestation (aRR: 1.31; 95 % CI: 1.04, 1.64). Further analysis of PM_2.5 constituents showed that prenatally exposed to high SO₄^2- was associated with the risk of non-optimal gross motor development (aRR: 1.40; 95 % CI: 1.08, 1.81). Null associations were observed for the rest four neurodevelopment domains. Collectively, our study suggested that prenatal exposure to PM_2.5, particularly with high SO₄^2- concentration, was associated with children's non-optimal gross motor development at 1 year old. The short- and long-term influences of perinatal PM_2.5 exposure on children's neurodevelopment warrant further investigation.