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Updated: Sep 7, 2025
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Microbiome-Immune Interactions in Allergy and Asthma
Yvonne J Huang1, Cara Porsche2, Ariangela J Kozik3
1Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan, Ann Arbor, Mich; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Mich.
The human microbiota influences immune responses, impacting allergy and asthma development. This review explores how microbiome changes, especially in early life, contribute to immune dysfunction and disease.
Area of Science:
- Immunology
- Microbiology
- Environmental Health
Background:
- The human microbiota is crucial for host immunity.
- Environmental exposures alter microbiome composition and function.
- Microbiome-immune interactions influence health and disease.
Purpose of the Study:
- To review recent findings on microbial-immune interactions in allergy and asthma.
- To explore how early-life microbiome perturbation affects immune dysfunction.
- To examine microbiome features related to allergy and asthma phenotypes.
Main Methods:
- Literature review of recent findings.
- Analysis of microbial-immune interactions.
- Focus on early life and established disease.
Main Results:
- Microbiome alterations are linked to immune dysfunction in allergy and asthma.
- Early life exposures can perturb the microbiome, leading to later immune issues.
- Specific microbiome features correlate with allergy and asthma symptoms.
Conclusions:
- Microbial-immune interactions are central to allergy and asthma pathogenesis.
- Targeting the microbiome may offer therapeutic strategies for immune-related diseases.
- Understanding microbiome dynamics is key for preventing and treating allergy and asthma.
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