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Updated: Sep 7, 2025

Sperm Collection of Differential Quality Using Density Gradient Centrifugation
Published on: November 29, 2018
The male infertility evaluation still matters in the era of high efficacy assisted reproductive technology
Joshua K Calvert1, Kiarad Fendereski1, Mohammadali Ghaed2
1Division of Urology, Department of Surgery, University of Utah Health, Salt Lake City, Utah.
Abstract:
Today's reproductive endocrinology and infertility providers have many tools at their disposal when it comes to achieving pregnancy. In the setting of highly efficacious assisted reproductive technology, it is natural to assume that male factor infertility can be overcome by acquiring sperm and then bypassing the male evaluation. In this review, we go through guideline statements and a stepwise male factor infertility evaluation to propose that a thorough male evaluation remains important to optimize pregnancy and live birth. The foundation of this parallel evaluation is referral to a reproductive urologist for the optimization of the male partner, for advanced diagnostics and interventions, and for the detection of other underlying male pathology. We also discuss what future developments might have an impact on the workup of the infertile male.
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