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Insulin use in type II diabetic patients: a predictive of mortality in covid-19 infection

Marc Assaad1, Nakisa Hekmat-Joo2, Jeff Hosry2

  • 1Department of Internal Medicine, Staten Island University Hospital, Staten Island, NY, 10305, USA. massaad@northwell.edu.

Diabetology & Metabolic Syndrome
|June 20, 2022
PubMed

Insights

Diabetic patients using insulin who contracted COVID-19 pneumonia faced worse outcomes and higher mortality rates compared to those on oral medications. This highlights the need for close monitoring of insulin-dependent diabetics during the pandemic.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) has caused a global health crisis.
  • Diabetes mellitus is a known risk factor for severe COVID-19 outcomes.
  • The comparative risk for different diabetes management groups remains unclear.

Purpose of the Study:

  • To compare disease severity and mortality rates in diabetic patients with COVID-19 pneumonia.
  • To differentiate risks between insulin users and non-insulin users.

Main Methods:

  • Retrospective case-control study of adult diabetic patients admitted with COVID-19 pneumonia.
  • Comparison of baseline characteristics and outcomes between home insulin users (cases) and non-insulin users (controls).
  • Cox regression analysis to assess the association between home insulin use and mortality.

Main Results:

  • 696 diabetic patients with COVID-19 pneumonia were analyzed.
  • Insulin users (cases) had higher rates of hypertension and hemoglobin A1c > 8.1% compared to controls.
  • Home insulin use was independently associated with an increased risk of death (Hazard Ratio: 1.92).

Conclusions:

  • Diabetic patients on home insulin with COVID-19 pneumonia experience worse outcomes and increased mortality.
  • Close monitoring of insulin-dependent diabetic patients is crucial during the pandemic.
  • Findings suggest distinct risk profiles within the diabetic population regarding COVID-19 severity.
Abstract

Keywords:
CoronavirusCovid-19HbA1cInflammatory markersInsulinInsulin ResistanceInvasive ventilationMechanical ventilationSARS-CoV-2Type II Diabetes mellitus

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