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Establishing a Diaphyseal Femur Fracture Model in Mice
Published on: December 9, 2022
[Distal femoral fractures]
S Barzen1, S Buschbeck2, R Hoffmann2
1Berufsgenossenschaftliche Unfallklinik Frankfurt am Main, Unfallchirurgie und orthopädische Chirurgie, Friedberger Landstr. 430, 60389, Frankfurt am Main, Deutschland. stefan.barzen@bgu-frankfurt.de.
Clinical Issue:
Fractures of the distal femur represent rare but serious injuries with a high 1‑year mortality. An increasingly older patient population requires adapted treatment concepts.
Standard Treatment Procedure:
Surgical treatment using angular stable plating and retrograde nailing is the standard procedure. Conservative treatment is only indicated in cases of low demands and high perioperative risks of the patient.
Treatment Innovations:
Primary double plate osteosynthesis and primary implantation of a distal femoral replacement represent new treatment procedures and show promising initial results in the collective of geriatric patients.
Diagnostic Work-Up:
Conventional radiographs in 2 planes and computed tomography with multiplanar and 3D reconstructions should be performed to enable an adequate assessment of the indications and treatment planning.
Performance:
Nonunion rates of plate and nail osteosyntheses range from 4% to 10%. No significant differences in long-term results can be observed. The results regarding double plate osteosynthesis and distal femoral replacement so far do not show any disadvantages compared to the existing procedures but there is still insufficient data for general recommendations.
Assessment:
Complex fractures with extensive reconstructive procedures and treatment by distal femoral replacement should be performed in specialized centers.
Practical Recommendations:
The gold standard is still surgical treatment by means of minimally invasive angular stable plate or retrograde nail osteosynthesis. Complex fracture forms require individual treatment planning considering all currently available treatment options.
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