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The prognostic value of aspartate beta-hydroxylase in early breast cancer
Paola Barboro1, Alessandra Rubagotti2, Silvia Poddine3
1Proteomic and Mass Spectrometry Unit, 9246IRCCS Ospedale Policlinico San Martino, 16132, Genoa, Italy.
Purpose:
Aspartate beta-hydroxylase (ASPH) is a transmembrane protein involved in cancer progression, which has been shown to imply a worse prognosis in several solid tumors. The aim of the present study was to further investigate the prognostic value of ASPH in early breast cancer.
Methods:
ASPH expression was investigated through immunohistochemistry in a cohort of 153 breast cancer patients with long-term follow-up, and correlated with clinical-pathological features plus all-cause and breast-cancer-specific mortality. Appropriate statistics were utilized.
Results:
ASPH negatively correlated with all-cause and breast-cancer-specific mortality.
Conclusions:
The results of this cohort study support the prognostic value of ASPH in early breast cancer.
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