Related Experiment Video
Updated: Sep 7, 2025
08:27
Bronchoalveolar Lavage Exosomes in Lipopolysaccharide-induced Septic Lung Injury
Published on: May 21, 2018
11.0K
Classic Signaling Pathways in Alveolar Injury and Repair Involved in Sepsis-Induced ALI/ARDS: New Research Progress
Wenli Li1,2, Duo Li1,2, Yuansen Chen1,2
1Institute of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.
Disease Markers
|June 21, 2022
Summary
Sepsis can cause acute lung injury (ALI) or acute respiratory distress syndrome (ARDS), a critical condition with high mortality. This review explores key signaling pathways involved in sepsis-induced ALI/ARDS, offering potential new therapeutic targets.
Area of Science:
- Pulmonary Medicine
- Critical Care
- Molecular Biology
Background:
- Sepsis is a life-threatening condition causing millions of deaths annually.
- Sepsis frequently leads to Acute Lung Injury (ALI) or Acute Respiratory Distress Syndrome (ARDS), characterized by diffuse alveolar injury, hypoxemia, and respiratory distress.
- ALI/ARDS carries a high mortality rate (30-40%) and current treatments, including lung-protective ventilation and fluid management, lack specificity.
Purpose of the Study:
- To review the signaling pathways implicated in alveolar injury and repair during sepsis-induced ALI/ARDS.
- To summarize recent research advancements in understanding these pathways.
- To identify potential novel therapeutic targets for sepsis-induced ALI/ARDS.
Main Methods:
- Literature review focusing on basic research of ALI/ARDS.
- Analysis of signaling pathways involved in sepsis-induced lung injury.
- Synthesis of current knowledge on molecular mechanisms.
Main Results:
- Identified key signaling pathways including NF-κB, JAK2/STAT3, MAPK, mTOR, and Notch.
- Detailed the role of these pathways in the pathogenesis of sepsis-induced ALI/ARDS.
- Highlighted the complex interplay of these pathways in alveolar injury and repair.
Conclusions:
- Understanding the molecular mechanisms of identified signaling pathways is crucial for developing effective treatments.
- These pathways represent promising targets for novel therapeutic strategies against sepsis-induced ALI/ARDS.
- Further research into these signaling pathways may provide new avenues for clinical intervention.
Related Concept Videos
01:20The JAK-STAT Signaling Pathway
9.2K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.2K
01:29Pneumonia II: Pathophysiology
520
The pathophysiology of pneumonia involves the following steps:
520
01:21Acute Respiratory Failure-II
345
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
345
01:19Interactions Between Signaling Pathways
6.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.4K
03:14Notch Signaling Pathway
4.4K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.4K
01:21Acute Respiratory Failure-I
310
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
310