Population Attributable Risks of Potential Modifiable Factors for Atrial Fibrillation in China: A National Survey

Zhiqiang Nie1,2, Hongbin Xu2, Chen Chen3

  • 1Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People's Republic of China.

Insights

Over half of atrial fibrillation (AF) cases in China are preventable. Addressing modifiable risk factors like hypertension can significantly reduce the AF burden and improve public health outcomes.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Atrial fibrillation (AF) is linked to increased mortality and reduced mobility.
  • The preventable burden of AF in China due to modifiable risk factors remains unclear.

Purpose of the Study:

  • To determine the proportion of AF burden in China attributable to modifiable risk factors.
  • To identify key modifiable risk factors for AF in the Chinese adult population.

Main Methods:

  • A cross-sectional study of 726,451 adults aged ≥40 years in China.
  • Identified seven modifiable risk factors: BMI, smoking, alcohol, physical inactivity, hypertension, diabetes, dyslipidemia.
  • Calculated population-attributable risks (PARs) using odds ratios (ORs).

Main Results:

  • The overall prevalence of AF was 2.6% (18,736 cases).
  • Hypertension, diabetes, and dyslipidemia showed the highest adjusted odds ratios for AF.
  • Nearly 60% of AF cases were attributable to the seven modifiable risk factors.

Conclusions:

  • Hypertension is the primary preventable risk factor for AF in China.
  • More than half of all AF cases in China could potentially be prevented by managing modifiable risk factors.
Abstract

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