Haplogroup diversity in the Indian population using 23 Y-STRs

Area of Science:

• Forensic Genetics
• Population Genetics
• Molecular Anthropology

Background:

• Y-STR polymorphism studies are valuable tools for forensic DNA analysis and molecular anthropology.
• Understanding the genetic landscape of male lineages is crucial for population studies.

Purpose of the Study:

• To explore the genetic scenario of the male lineage in Madhya Pradesh, India.
• To evaluate the utility of the PowerPlex® Y 23 multiplex system for forensic and human genetics applications.
• To determine the population structure and affinities of the Madhya Pradesh population.

Main Methods:

• Y-STR genotyping of 511 unrelated male blood samples using the PowerPlex® Y 23 system.
• Capillary electrophoresis for fragment separation and Y-STR profiling.
• Statistical analyses including AMOVA, PCoA, MDS plots, and haplogroup prediction.

Main Results:

• Generated Y-STR profiles for 23 forensic-relevant markers.
• Demonstrated the effectiveness of the PowerPlex® Y 23 system in the Madhya Pradesh population.
• Haplogroup analysis indicated multi-geographic origins and multi-ethnic genetic affinities.

Conclusions:

• The PowerPlex® Y 23 system is valuable for forensic and human genetics in Madhya Pradesh.
• Y-STR data provides insights into the complex origins and genetic diversity of the region's population.