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Updated: Sep 7, 2025
07:59
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
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Biosynthesis of cyclitols
Fumitaka Kudo1, Tadashi Eguchi1
1Department of Chemistry, Tokyo Institute of Technology, 2-12-1 O-Okayama, Meguro-ku, Tokyo, Japan. fkudo@chem.titech.ac.jp.
Natural Product Reports
|June 21, 2022
Summary
This review explores naturally occurring cyclitols, stable carbohydrate derivatives crucial for cellular water solubility. It categorizes cyclitols by their unique carbocycle-forming enzymatic reactions and discusses their biosynthesis and modification pathways.
Area of Science:
- Biochemistry
- Carbohydrate Chemistry
- Enzymology
Background:
- Cyclitols are stable, hydrophilic carbohydrate derivatives enhancing cellular water solubility.
- Their stability stems from carbocyclic structures lacking acetal groups, unlike sugars.
- Carbocycle-forming reactions are essential for cyclitol biosynthesis.
Purpose of the Study:
- To review naturally occurring cyclitols identified up to 2021.
- To categorize cyclitols based on carbocycle-forming enzymatic reactions.
- To examine the mechanisms of cyclitol-forming enzymes and subsequent modifications.
Main Methods:
- Literature review of cyclitols and their biosynthesis.
- Classification of cyclitols by enzymatic carbocycle formation.
- Analysis of enzymatic reaction mechanisms and cyclitol modification pathways.
Main Results:
- Comprehensive catalog of identified natural cyclitols.
- Categorization based on distinct carbocycle-forming enzymatic reactions.
- Detailed insights into cyclitol biosynthesis and post-formation modifications.
Conclusions:
- Carbocycle-forming enzymatic reactions are central to cyclitol diversity.
- Understanding these pathways is key to cyclitol biosynthesis and function.
- This review provides a foundational resource on natural cyclitols and their formation.
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