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The predictive value of hemoglobin to creatinine ratio for contrast-induced nephropathy in percutaneous coronary

Sencer Çamci1, Mustafa Kinik1, Selma Ari1

  • 1Department of Cardiology, Bursa Postgraduate Hospital, Bursa, Turkey.

Clinical Chemistry and Laboratory Medicine
|June 21, 2022
PubMed

Insights

The hemoglobin to creatinine ratio can predict contrast-induced nephropathy (CIN) in patients undergoing percutaneous coronary intervention (PCI). A lower ratio indicates a higher risk of developing CIN after the procedure.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarkers

Background:

  • Contrast-induced nephropathy (CIN) is a significant risk following percutaneous coronary intervention (PCI).
  • Predictive markers for CIN are crucial for patient management and risk stratification.

Purpose of the Study:

  • To evaluate the predictive value of the hemoglobin to creatinine ratio for CIN development in patients undergoing PCI.
  • To identify key predictors of CIN in this patient population.

Main Methods:

  • Prospective evaluation of 500 patients undergoing PCI.
  • Calculation of baseline hemoglobin to creatinine ratio and glomerular filtration rate (GFR).
  • Definition of CIN based on serum creatinine increase 48-72 hours post-contrast.

Main Results:

  • CIN developed in 13.8% of patients.
  • Hemoglobin to creatinine ratio, ejection fraction (EF), and contrast amount were significant predictors of CIN.
  • Receiver operating characteristic (ROC) analysis showed good predictive performance for these markers (AUCs ranging from 0.694 to 0.731).

Conclusions:

  • The hemoglobin to creatinine ratio is an independent predictor of CIN in patients undergoing PCI.
  • EF and contrast amount also independently predict CIN development.
  • These findings highlight the utility of the hemoglobin to creatinine ratio as a simple predictive tool for CIN.
Abstract

Keywords:
contrast induced nephropathycreatinineejection fractionhemoglobinpercutaneous coronary intervention

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