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Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
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Direct determination of benzalkonium chloride in ophthalmic systems by reversed-phase high-performance liquid
Abstract:
High-performance liquid chromatography has been used to quantitate benzalkonium chloride (alkylbenzyldimethylammonium chloride) in complex ophthalmic formulations at or below concentration levels of 50 ppm. The method involves a one-step dilution for sample preparation and direct injection; therefore, recovery and/or conversion problems are nonexistent. The assay is quick, specific, reproducible, and simple. This new approach makes routine determinations far simpler than previous methods and is especially useful for product stability studies and quality control procedures.
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