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Gastroschisis for the Gastroenterologist: Updates on Epidemiology, Management, and Outcomes
Salina Khushal1, Mitchell R Ladd2, Jennifer B Fundora3
1From the Division of Pediatric Gastroenterology, Hepatology and Nutrition, Johns Hopkins University School of Medicine, Baltimore, MD.
Insights
Gastroschisis, a congenital abdominal wall defect, is increasingly common. Early detection and multidisciplinary care improve outcomes for affected infants.
Area of Science:
- Pediatric Surgery
- Neonatology
- Maternal-Fetal Medicine
Background:
- Gastroschisis is a prevalent congenital abdominal wall defect with rising incidence in the US.
- Environmental factors in utero are suspected contributors to gastroschisis.
- Prenatal screening and care have standardized early detection of gastroschisis.
Purpose of the Study:
- To review current management strategies for gastroschisis.
- To highlight the importance of multidisciplinary care in optimizing outcomes.
- To discuss common postoperative challenges and long-term prognosis.
Main Methods:
- Review of current literature on gastroschisis management.
- Analysis of surgical techniques, including sutureless closure.
- Discussion of diagnostic and therapeutic approaches.
Main Results:
- Sutureless closure is increasingly utilized in surgical management.
- Postoperative feeding difficulties and necrotizing enterocolitis are common complications.
- Infants with simple gastroschisis generally achieve catch-up growth, while complex cases face higher morbidity and mortality.
Conclusions:
- Optimal management of gastroschisis necessitates a collaborative perinatal team approach.
- Vigilance for complications and tailored care are crucial for infants with gastroschisis.
- Multidisciplinary collaboration ensures the best possible long-term outcomes for affected neonates.
Abstract:
Gastroschisis is a common congenital abdominal wall defect, likely influenced by environmental factors in utero, with increasing prevalence in the United States. Early detection of gastroschisis in utero has become the standard with improved prenatal care and screening. There are multiple surgical management techniques, though sutureless closure is being used more frequently. Postoperative feeding difficulty is common and requires vigilance for complications, such as necrotizing enterocolitis. Infants with simple gastroschisis are expected to have eventual catch-up growth and normal development, while those with complex gastroschisis have higher morbidity and mortality. Management requires collaboration amongst several perinatal disciplines, including obstetrics, maternal fetal medicine, neonatology, pediatric surgery, and pediatric gastroenterology for optimal care and long-term outcomes.
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