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There are many research methods available to psychologists in their efforts to understand, describe, and explain behavior and the cognitive and biological processes that underlie it.

Clearance Models: Compartment Models

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Clearance measures drug elimination from the central compartment, including plasma and highly perfused organs like kidneys and liver. Its calculation varies depending on pharmacokinetic models and administration routes. The one-compartment model, for instance, portrays the pharmacokinetics of polar drugs such as aminoglycoside antibiotics administered intravenously and readily excreted in urine. In this case, clearance is influenced by the terminal rate constant (λz) and the total volume...

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Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage

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Case 307.

Paul Sathiadoss¹, Najla Fasih¹

¹From the Department of Medical Imaging, The Ottawa Hospital, University of Ottawa, 501 Smyth Rd, Ottawa, ON, Canada K1H 8L6.

|June 21, 2022

Summary

This summary is machine-generated.

A 45-year-old woman experienced chronic nausea and vomiting. Diagnostic imaging, including CT and an indium 111 octreotide scan, was used to investigate her unexplained symptoms.

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Area of Science:

Gastroenterology
Nuclear Medicine
Radiology

Background:

A 45-year-old woman presented with a 4-year history of worsening nausea, nonbilious vomiting, and mild upper abdominal pain.
Routine investigations and tumor markers were unremarkable, necessitating further diagnostic evaluation.

Observation:

Clinical examination revealed stable vital signs and a benign abdominal exam.
Initial contrast-enhanced CT of the abdomen and pelvis showed no definitive pathology.
An indium 111 octreotide scan was performed subsequently for further assessment.

Findings:

The patient's prolonged gastrointestinal symptoms were unexplained by initial laboratory and imaging studies.
The diagnostic workup involved a multi-modal imaging approach.

Implications:

This case highlights the importance of considering advanced imaging techniques when initial evaluations are inconclusive for chronic gastrointestinal complaints.
Further investigation with somatostatin receptor scintigraphy (indium 111 octreotide scan) may be beneficial in diagnosing rare conditions presenting with unexplained nausea and vomiting.