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Related Experiment Videos

Anterior chamber lenses. Part II: A laboratory study.

D J Apple, S O Hansen, S C Richards

    Journal of Cataract and Refractive Surgery
    |March 1, 1987
    PubMed
    Summary

    Small-diameter, closed-loop anterior chamber intraocular lenses (IOLs) were found to be unsafe and ineffective in a study of explanted IOLs. These IOL designs should be discontinued and monitored by the FDA.

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    Area of Science:

    • Ophthalmology
    • Biomaterials Science
    • Medical Device Analysis

    Background:

    • Anterior chamber intraocular lenses (IOLs) are widely used for vision correction.
    • Previous designs have raised concerns regarding long-term safety and efficacy.
    • Understanding the performance of different IOL designs is crucial for patient outcomes.

    Purpose of the Study:

    • To analyze the types and prevalence of explanted anterior chamber IOLs.
    • To evaluate the safety and efficacy of different anterior chamber IOL designs based on histopathologic findings and clinical histories.
    • To provide recommendations regarding the use and regulation of specific IOL designs.

    Main Methods:

    • Analysis of 606 surgically removed anterior chamber IOL specimens.

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  • Histopathologic examination of explanted IOLs.
  • Correlation of histopathologic findings with available clinical histories.

    • Main Results:

    • 58% of explanted IOLs were small-diameter, round loop, closed-loop designs.
    • One-piece, all-PMMA IOLs showed favorable performance.
    • Closed-loop designs were disproportionately represented in the explanted sample compared to market share.

    Conclusions:

    • Small-diameter, closed-loop anterior chamber IOLs are associated with poor safety and efficacy.
    • Implantation of these specific IOL designs is no longer warranted.
    • Recommendations include FDA recall/monitoring and discontinuation of closed-loop IOLs in the US.