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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

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The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
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Molecular Factors Affecting Cell Division01:27

Molecular Factors Affecting Cell Division

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Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
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What is the Cell Cycle?01:04

What is the Cell Cycle?

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The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the original...
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Negative Regulator Molecules01:23

Negative Regulator Molecules

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Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
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Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

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In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
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Related Experiment Video

Updated: Sep 7, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

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Cell biology: How to short-circuit the cell cycle.

Michael L Goldberg1, Gemunu H Gunaratne2

  • 1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.

Current Biology : CB
|June 21, 2022
PubMed
Summary

Cell cycle progression can be altered, repeating or skipping stages. A new study reveals how molecular

Area of Science:

  • Cell Biology
  • Molecular Biology

Background:

  • The cell cycle is a tightly regulated process essential for cell division and organism development.
  • Normal cell cycle progression follows a specific sequence: G1, S, G2, and M phases.

Purpose of the Study:

  • To investigate the mechanisms by which cell cycle progression can be altered.
  • To understand how molecular 'latches' ensure orderly cell cycle progression.

Main Methods:

  • The study involved experimental manipulations of the cell cycle.
  • Analysis of molecular components regulating cell cycle transitions.

Main Results:

  • Certain manipulations can 'short circuit' the normal cell cycle.
  • These alterations lead to repetitions of some stages and skipping of others.

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Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
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Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry

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Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
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Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

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Related Experiment Videos

Last Updated: Sep 7, 2025

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

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Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry
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Measuring Cell Cycle Progression Kinetics with Metabolic Labeling and Flow Cytometry

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Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization
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Temporal Tracking of Cell Cycle Progression Using Flow Cytometry without the Need for Synchronization

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  • The study identified how these changes affect the function of molecular 'latches'.

    • Conclusions:

    • Molecular 'latches' play a crucial role in maintaining orderly cell cycle progression.
    • Disruption of these 'latches' can lead to aberrant cell cycle dynamics.
    • Understanding these mechanisms is key to comprehending cell division control.