Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Peak with a pain" - Description of a rare posterior fossa "Mountain peak" shape presenting with trigeminal neuralgia.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2025
Same author

From farm to field: testing different biocrust cultivation approaches and application techniques in the Sonoran Desert.

Restoration ecology·2025
Same author

Formation of the NSI-Young Neurosurgeons Forum and the Fellowship Landscape in India: Wants vs Needs.

Neurology India·2025
Same author

Rare tandem anomalies of the vertebral artery at the craniovertebral junction - What the mind does not know the eyes do not see!!

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2025
Same author

Carpal tunnel release surgery restores force control but not force coordination in CTS patients.

Scientific reports·2025
Same author

The Normal Static Two-Point Discrimination in the Palmar Aspect of Hand in Adults and Children in a Sample Indian Population.

Indian journal of plastic surgery : official publication of the Association of Plastic Surgeons of India·2024

Related Experiment Video

Updated: Sep 7, 2025

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

19.9K

Stimulation-induced changes at the electrode-tissue interface and their influence on deep brain stimulation.

J Evers1,2, K Sridhar1,2, J Liegey1

  • 1School of Electrical and Electronic Engineering, University College Dublin, Dublin, Ireland.

Journal of Neural Engineering
|June 21, 2022
PubMed
Summary
This summary is machine-generated.

Chronic deep brain stimulation (DBS) alters the electrode-tissue interface (ETI), impacting electrical properties and neural activation. Understanding these ETI changes is crucial for optimizing future DBS systems, especially closed-loop and sensing applications.

Keywords:
Parkinson’s diseaseanimal modelcomputational modeldeep brain stimulationelectrode–tissue interfaceprotein adsorption

More Related Videos

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.0K
Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

263.3K

Related Experiment Videos

Last Updated: Sep 7, 2025

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation
10:52

Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation

Published on: October 2, 2015

19.9K
Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
14:14

Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models

Published on: August 12, 2018

9.0K
Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

263.3K

Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Materials Science

Background:

  • The electrode-tissue interface (ETI) is critical for deep brain stimulation (DBS) efficacy.
  • Chronic DBS effects on ETI, including glial scarring and electrical double layer (EDL) changes, remain largely uncharacterized.
  • Understanding ETI dynamics is vital for advancing DBS technology.

Purpose of the Study:

  • To characterize chronic DBS-induced changes at the ETI in a rat model.
  • To investigate the impact of these ETI alterations on electrical properties and neural activation.
  • To develop a computational model for simulating ETI effects on DBS.

Main Methods:

  • Chronic implantation of DBS electrodes in rats with and without daily stimulation for up to 8 weeks.
  • Impedance and histological analysis of the ETI.
  • Development of a computational model based on experimental data to estimate dielectric properties and simulate stimulation effects.
  • In vitro examination of stimulated electrodes.

Main Results:

  • Chronic DBS significantly altered ETI properties, including dielectric characteristics of the EDL and encapsulation tissue.
  • Simulations revealed that stimulation-induced ETI changes influence electric field distribution and neural activation patterns, particularly in voltage-controlled stimulation.
  • High-frequency stimulation in vitro caused protein desorption and reduced electrode impedance.

Conclusions:

  • Chronic DBS induces measurable changes in the ETI, affecting its electrical properties.
  • These ETI modifications can alter neural activation during DBS, with implications for stimulation parameters.
  • Findings are critical for the design of next-generation DBS systems, including adaptive and sensing-integrated devices.