Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

9.8K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.8K
Archaeal Cell Wall01:29

Archaeal Cell Wall

205
Archaeal cell walls are structurally and compositionally distinct from their bacterial counterparts, lacking the characteristic peptidoglycan layer found in most bacteria. Instead, archaeal cell walls exhibit remarkable diversity, utilizing materials such as pseudomurein, polysaccharides, and proteins to construct their protective outer layers. This structural flexibility is closely tied to archaea's ecological adaptability.S-Layers: The Common Archaeal Cell WallThe S-layer is the most...
205
Antimicrobial Proteins01:23

Antimicrobial Proteins

4.9K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
4.9K
Microbial Morphologies01:29

Microbial Morphologies

739
Bacterial and archaeal cells exhibit remarkable diversity in shape and structure, critical in their adaptability and functionality. Among bacteria, the most commonly observed shapes include cocci and bacilli. Cocci are spherical and may exist singly or in groupings such as pairs (diplococci), chains (streptococci), clusters (staphylococci), or tetrads. Bacilli, in contrast, are rod-shaped and can also occur as single cells, in pairs, or chains, depending on their environmental and genetic...
739
Oligosaccharide Assembly01:24

Oligosaccharide Assembly

3.0K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
3.0K
Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

108
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
108

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Many Lives of a Single Sequence: Functional Plasticity Through Amyloid Polymorphism.

Sub-cellular biochemistry·2026
Same author

Structural and Functional Versatility of the Amyloidogenic Non-Amidated Variant of the Antimicrobial Peptide Citropin 1.3.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2025
Same author

Sla2 is a core interaction hub for clathrin light chain and the Pan1/End3/Sla1 complex.

Structure (London, England : 1993)·2025
Same author

Resilience and charge-dependent fibrillation of functional amyloid: Interactions of Pseudomonas biofilm-associated FapB and FapC amyloids.

The Journal of biological chemistry·2024
Same author

Staphylococcus aureus functional amyloids catalyze degradation of β-lactam antibiotics.

Nature communications·2023
Same author

What can AlphaFold do for antimicrobial amyloids?

Proteins·2023

Related Experiment Video

Updated: Sep 7, 2025

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.2K

Structural Mimicry in Microbial and Antimicrobial Amyloids.

Nimrod Golan1, Yizhaq Engelberg1, Meytal Landau1,2

  • 1Department of Biology, Technion-Israel Institute of Technology, Haifa, Israel;

Annual Review of Biochemistry
|June 21, 2022
PubMed
Summary

Microbial amyloids, protein fibrils from microbes, have diverse roles in host interactions and disease. Their structures are key to understanding and developing new antimicrobial and antivirulence agents.

Keywords:
amyloidsantimicrobialatomic structurescross-αcross-βfibrilsinfectionsmicrobesmimicryneurodegeneration

More Related Videos

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
15:04

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

6.0K
Biomimetic Materials to Characterize Bacteria-host Interactions
12:22

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

9.5K

Related Experiment Videos

Last Updated: Sep 7, 2025

Rapid Generation of Amyloid from Native Proteins In vitro
05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.2K
Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils
15:04

Interactions with and Membrane Permeabilization of Brain Mitochondria by Amyloid Fibrils

Published on: September 28, 2019

6.0K
Biomimetic Materials to Characterize Bacteria-host Interactions
12:22

Biomimetic Materials to Characterize Bacteria-host Interactions

Published on: November 16, 2015

9.5K

Area of Science:

  • Microbiology
  • Biochemistry
  • Structural Biology

Background:

  • Microbial pathogens and microbiomes produce secreted amyloids with roles in virulence and host interactions.
  • Human amyloids are linked to neurodegenerative diseases, but interspecies amyloid interactions may also be significant.
  • Amyloid structures show connections to antimicrobial activity and neuroimmune functions.

Purpose of the Study:

  • To explore the structural diversity and functional significance of microbial and antimicrobial amyloids.
  • To compare microbial amyloids with human amyloids and identify novel therapeutic targets.
  • To investigate the potential of amyloidogenic sequences in host-microbe interactions and disease.

Main Methods:

  • Analysis of emerging high-resolution structures of microbial and antimicrobial amyloids.
  • Comparison of structural features between microbial and human amyloids.
  • Postulation of amyloidogenic sequences as targets for structural mimicry.

Main Results:

  • Recent structures reveal similarities and differences between microbial and human amyloids.
  • Microbial amyloids exhibit diverse activities, distinct from typical amyloid motifs.
  • Structural insights support the role of amyloids in host-microbe interactions.

Conclusions:

  • Microbial amyloid structures are crucial for understanding their diverse functions.
  • Research into microbial amyloids can lead to novel antivirulence and antimicrobial agents.
  • Targeting microbial amyloids may offer therapeutic strategies for infections and diseases.