Holmium-166 Radioembolization: Current Status and Future Prospective

Area of Science:

• Nuclear Medicine
• Radiotherapy
• Oncology

Background:

• Holmium-166 (166Ho) is a therapeutic isotope with potential for liver radioembolization.
• Its unique properties include beta and gamma emission, and lanthanide characteristics.

Purpose of the Study:

• To provide an overview of 166Ho liver radioembolization.
• To discuss the clinical workflow, findings, and future prospects of 166Ho in this application.

Main Methods:

• Review of existing literature and clinical data on 166Ho liver radioembolization.
• Analysis of imaging capabilities (SPECT, MRI) and treatment planning aspects.

Main Results:

• 166Ho offers dual imaging capabilities (SPECT and MRI) due to its emission properties.
• The use of the same particle for scouting and treatment enables individualized procedures.
• Potential for enhanced dosimetry-based patient selection and treatment planning.

Conclusions:

• 166Ho is a promising isotope for liver radioembolization, offering advanced imaging and personalized treatment options.
• Further clinical evaluation and workflow optimization are expected to enhance its application.