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Updated: Sep 7, 2025

Author Spotlight: Traditional Chinese Medicine for Sleep Disorders in Acute COPD &#8212; A Safe, Cost-Effective Approach
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Soluble RAGE in COPD, with or without coexisting obstructive sleep apnoea.

Marta Marin-Oto1, David Sanz-Rubio1, Fernando Santamaría-Martos2

  • 1Translational Research Unit, Aragón Health Research Institute, Zaragoza, Spain.

Respiratory Research
|June 21, 2022
PubMed
Summary

Soluble receptor for advanced glycation end-products (sRAGE) levels are lower in COPD and OSA patients. Continuous positive airway pressure (CPAP) treatment may improve sRAGE levels in OSA patients, including those with COPD.

Keywords:
Chronic obstructive pulmonary diseaseObstructive sleep apnoeaSmokerssRAGE

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Area of Science:

  • Pulmonary Medicine
  • Biomarker Research
  • Sleep Medicine

Background:

  • Hypoxia is linked to reduced levels of soluble receptor for advanced glycation end-products (sRAGE).
  • sRAGE is an emerging anti-inflammatory biomarker relevant to Chronic Obstructive Pulmonary Disease (COPD).
  • This study investigates sRAGE in hypoxia-related conditions: COPD, Obstructive Sleep Apnea (OSA), and their overlap.

Purpose of the Study:

  • To assess plasma levels of sRAGE in patients with COPD, OSA, and overlapping conditions.
  • To evaluate changes in sRAGE levels over one year.
  • To determine the effect of continuous positive airway pressure (CPAP) on sRAGE levels.

Main Methods:

  • Plasma sRAGE levels were measured in 317 subjects at baseline and 294 after one year.
  • Participant groups included healthy non-smokers (HNS), healthy smokers (HS), OSA, COPD, and OSA-COPD overlap patients.
  • Statistical adjustments were made for age, sex, smoking status, and BMI.

Main Results:

  • Adjusted sRAGE levels were significantly reduced in OSA (-12.5%), COPD (-14.8%), and OSA-COPD overlap (-12.3%) compared to HNS.
  • No significant differences in sRAGE were found between overlap patients and those with OSA or COPD alone.
  • sRAGE levels did not change in untreated patients but increased significantly in OSA and OSA-COPD overlap patients treated with CPAP.

Conclusions:

  • Reduced sRAGE levels are observed in both COPD and OSA.
  • CPAP treatment shows potential for improving sRAGE levels in OSA patients, including those with comorbid COPD.