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A Polyaniline-based Sensor of Nucleic Acids
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Structure-Dependent Nontraditional Intrinsic Fluorescence of Aliphatic Hyperbranched Polyureas
1Key Laboratory of Sensing Technology and Biomedical Instrument of Guangdong Province, School of Biomedical Engineering, Shenzhen Campus of Sun Yat-sen University, Shenzhen, Guangdong 518107, China.
Bioconjugate Chemistry
|June 22, 2022
Summary
Aliphatic hyperbranched polyureas (aBPUs) exhibit nontraditional intrinsic fluorescence (NTIF) for label-free bioimaging. Increasing branching and forming nanoassemblies significantly enhance NTIF properties.
Area of Science:
- Polymer chemistry
- Materials science
- Biomedical engineering
Background:
- Nontraditional intrinsic fluorescence (NTIF) in heteroatom-containing polymers is crucial for label-free bioimaging.
- Aliphatic hyperbranched polyureas (aBPUs) show potential in nanomedicine due to controllable urea groups.
Purpose of the Study:
- To investigate the NTIF properties of aBPUs.
- To elucidate the structure-property relationships influencing aBPUs' NTIF.
- To explore the application of aBPUs in label-free imaging.
Main Methods:
- Synthesis of aBPUs with varying degrees of branching (DBs) and chemical modifications.
- Characterization of NTIF properties.
- Self-assembly of poly(ethylene glycol)-modified aBPUs (aBPUs-PEG) into nanospheres.
- In vitro imaging experiments.
Main Results:
- aBPUs display inherent NTIF, which increases with higher DBs.
- Chemical modifications impact NTIF; disruption of hydrogen bonding reduces fluorescence.
- aBPUs-PEG nanoassemblies show an 89% NTIF enhancement compared to solutions.
- Successful label-free material imaging using aBPUs-PEG nanoassemblies.
Conclusions:
- aBPUs are promising luminogens for NTIF applications.
- Structural design, including DB and nanoassembly, can tune NTIF.
- aBPUs-PEG nanoassemblies enable effective label-free imaging.
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