Related Experiment Video
Updated: Sep 7, 2025

Isolation of Double Negative αβ T Cells from the Kidney
Published on: May 16, 2014
The role of IL-10 in kidney disease
Wei Wei1, Yibo Zhao1, Yan Zhang1
1Department of Emergency Medicine, Tianjin Medical University General Hospital, Tianjin 300052, PR China.
Abstract:
Kidney disease is a global health problem with high mortality and socioeconomic burden, including acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy (DN),and lupus nephritis (LN). However, IL-10 is an anti-inflammatory factor. During severe infection in kidney disease, maintaining tissue homeostasis by inhibiting excessive inflammatory response, regulating immune suppression, delaying tissue fibrosis, and promoting tissue repair. Therefore, improving the pathogenesis and identifying effective therapeutic targets are significant for treating and diagnosing kidney diseases. Thus, the current review describes the structure and function of the IL-10 family and focuses on crucial role in kidney disease. We further discuss the regulatory mechanisms through which IL-10 is involved in kidney disease progression.
Related Concept Videos
Chronic Kidney Disease II: Clinical Manifestations
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury IV: Diagnostic Studies and Prevention
Chronic Kidney Disease I: Introduction
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Chronic Kidney Disease III: Interprofessional Care

