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Related Experiment Video

Updated: Sep 7, 2025

A 3D Organotypic Melanoma Spheroid Skin Model
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Melanoma.

Richard P Usatine1, Candrice R Heath2

  • 1Family and Community Medicine, Dermatology and Cutaneous Surgery, University of Texas Health, San Antonio.

The Journal of Family Practice
|June 22, 2022
PubMed
Summary
This summary is machine-generated.

This study compares two melanoma cases: acral lentiginous melanoma in a young Black woman and nodular melanoma in an older Hispanic woman. Both cases showed significant depth and positive lymph node involvement, highlighting aggressive melanoma characteristics.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Melanoma presents in various subtypes, each with distinct clinical and pathological features.
  • Acral lentiginous melanoma (ALM) and nodular melanoma (NM) are aggressive forms with significant metastatic potential.
  • Early detection and accurate staging are crucial for effective melanoma management.

Observation:

  • Case A: A 30-year-old Black woman with acral lentiginous melanoma on her foot (2 mm depth) and a positive sentinel lymph node biopsy.
  • Case B: A 63-year-old Hispanic woman with nodular melanoma on her shoulder (5.5 mm depth) and a positive sentinel lymph node biopsy.

Findings:

  • Both ALM and NM, despite differing locations and patient demographics, demonstrated significant depth and lymph node metastasis.
  • The findings highlight the potential for aggressive behavior in melanoma regardless of subtype or patient characteristics.

Implications:

  • This comparison underscores the importance of vigilant melanoma surveillance across all skin types and age groups.
  • Prompt diagnosis and comprehensive staging, including sentinel lymph node biopsy, are crucial for effective melanoma management.
  • Further research into subtype-specific risk factors and treatment strategies is warranted.