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Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
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Risk factors for oxaliplatin-induced peripheral neuropathy: a systematic review and meta-analysis
1School of Nursing, Zhejiang Chinese Medical University, Hangzhou, China.sunqiuhua@zcmu.edu.cn.
European Review for Medical and Pharmacological Sciences
|June 22, 2022
Summary
Oxaliplatin-induced neuropathy (OIPN) risk is linked to age, diabetes, and cumulative dose. Identifying these factors is crucial for preventing this common cancer therapy side effect.
Area of Science:
- Oncology
- Neuroscience
- Pharmacology
Background:
- Oxaliplatin is a key chemotherapy agent.
- Oxaliplatin-induced neuropathy (OIPN) is a frequent and dose-limiting side effect.
- Effective prevention strategies for OIPN are needed.
Purpose of the Study:
- To identify risk factors for OIPN.
- To provide evidence for improved OIPN prevention.
Main Methods:
- Comprehensive literature search of multiple databases (PubMed, Embase, etc.) for observational studies up to November 2021.
- Meta-analysis of 20 studies involving 10,900 participants.
- Assessment of study quality using the Newcastle-Ottawa Scale.
Main Results:
- Identified risk factors for OIPN include: age, gender, diabetes, anemia, hypomagnesemia, alcohol consumption, BMI, body surface area, cumulative oxaliplatin dose, and number of chemotherapy cycles.
- Smoking history and chemotherapy regimen were not associated with OIPN risk.
- Meta-analysis provided pooled estimates for various risk factors.
Conclusions:
- Multiple factors contribute to the risk of OIPN.
- Recognizing and addressing modifiable risk factors is essential for enhancing OIPN prevention and treatment.
- Further research into specific modifiable factors is warranted.
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