Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability: Overview01:13

Bioavailability: Overview

3.1K
Bioavailability refers to the proportion of an unaltered drug that, after administration, enters the systemic circulation and can be distributed to the desired action site. Factors such as gastrointestinal (GI) absorption and liver biotransformation influence the bioavailability of a drug when it is administered orally. When a drug is administered intravenously, it enters the systemic circulation directly; by definition, its bioavailability is assumed to be 100%. The bioavailability of an...
3.1K
Bioequivalence: Overview01:16

Bioequivalence: Overview

1.2K
Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
1.2K
Factors Influencing Bioavailability: First-Pass Elimination01:23

Factors Influencing Bioavailability: First-Pass Elimination

6.9K
When a drug is taken orally, it undergoes a journey starting from the gastrointestinal (GI) tract, passing through the portal vein, reaching the liver, and finally entering the systemic circulation. This process involves the absorption of the drug across the GI tract. The liver is the primary site for metabolizing the drug, with some metabolism also occurring in the gut wall. This journey significantly reduces the quantity of the drug that reaches the systemic circulation, a phenomenon known as...
6.9K
Non-Oral Extravascular Drug Absorption Routes01:15

Non-Oral Extravascular Drug Absorption Routes

286
Non-oral extravascular routes, which encompass sublingual, buccal, topical, intramuscular, and inhalation methods, primarily utilize passive diffusion to transport drugs into the systemic circulation. The absorption rates and effectiveness of these routes depend on the drug's physicochemical properties, as well as the patient's anatomical and pathophysiological state.
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
286
Drug Absorption Mechanism: Carrier-Mediated Membrane Transport01:19

Drug Absorption Mechanism: Carrier-Mediated Membrane Transport

4.3K
Certain large, lipid-insoluble drug molecules that resemble amino acids, peptides, or glucose, require specialized carrier proteins to facilitate their diffusion across cell membranes. This transport can occur through either facilitated diffusion, which does not require energy input, or active transport, which does require energy input.
Facilitated diffusion is a passive process that utilizes human Solute Carrier (SLC) transporters. These transporters bind to the drug, undergo structural...
4.3K
Drug Biotransformation: Overview01:16

Drug Biotransformation: Overview

2.8K
Pharmaceutical substances known as xenobiotics are predominantly lipophilic and nonionized. This enables them to permeate lipid bilayers, such as cell membranes, and interact with intracellular target receptors. Lipophilic drugs have an advantage in crossing biological barriers and reaching their intended sites of action. However, lipophilic drugs often have a restricted capacity for renal expulsion or elimination from the body. When these drugs enter the kidneys and undergo glomerular...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

High-Performance Coaxial Electrospun rGO/Ti<sub>3</sub>C<sub>2</sub>Tx MXene@PAN Nanofibers for Enhanced Electromagnetic Interference Shielding and Thermal Insulation at Extreme Environments.

ACS applied materials & interfaces·2026
Same author

Water-confined CuFe Prussian blue analogues empower Nafion membranes for high-temperature/low-humidity fuel cells.

Chemical communications (Cambridge, England)·2026
Same author

Coaxial Electrospun MXene/GO@PAN Nanofibers for High-Performance Electromagnetic Interference Shielding and Thermal Insulation.

ACS applied materials & interfaces·2026
Same author

High Performance Composite Thermochemical Heat Storage Materials Synthesized by Impregnation, Foaming, and Fibering: A Comprehensive Review.

ACS applied materials & interfaces·2026
Same author

Endoplasmic reticulum stress in antitumor immunity and immunotherapy resistance: mechanisms and therapeutic implications.

Molecular cancer·2026
Same author

Retraction notice to "Liposomal honokiol promotes hair growth via activating Wnt3a/β-catenin signaling pathway and down regulating TGF-β1 in C57BL/6N mice" [Biomedicine & Pharmacotherapy 141 (2021) 111793].

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

Related Experiment Video

Updated: Sep 7, 2025

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
07:42

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids

Published on: March 1, 2024

857

Core-shell alum-borneol fiber for high bioavailability.

Yarong Lv1, Yufen Han1, Zhongxun Yu1

  • 1Beijing Key Laboratory of Advanced Functional Polymer Composites, College of Material Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.

Progress in Biomaterials
|June 22, 2022
PubMed
Summary

This study developed novel alum-borneol polyvinyl pyrrolidone nanofibers to enhance burn treatment. The core-shell fibers significantly improved borneol solubility, offering a promising new therapeutic option.

Keywords:
Alum-borneolBioavailabilityCoaxial electrospinningCombined application

More Related Videos

Extraction of Lignin with High &#946;-O-4 Content by Mild Ethanol Extraction and Its Effect on the Depolymerization Yield
10:18

Extraction of Lignin with High β-O-4 Content by Mild Ethanol Extraction and Its Effect on the Depolymerization Yield

Published on: January 7, 2019

20.9K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.0K

Related Experiment Videos

Last Updated: Sep 7, 2025

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids
07:42

Author Spotlight: Development and Characterization of Eco-Friendly Lignin-Based Microparticles for Enhanced Delivery of Bioflavonoids

Published on: March 1, 2024

857
Extraction of Lignin with High &#946;-O-4 Content by Mild Ethanol Extraction and Its Effect on the Depolymerization Yield
10:18

Extraction of Lignin with High β-O-4 Content by Mild Ethanol Extraction and Its Effect on the Depolymerization Yield

Published on: January 7, 2019

20.9K
Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
09:34

Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Published on: February 9, 2019

9.0K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Nanotechnology

Background:

  • Burn treatment faces clinical challenges, with alum-borneol showing promise but limited by borneol's poor solubility.
  • Nanofiber drug delivery systems offer new therapeutic avenues for clinical applications.

Purpose of the Study:

  • To fabricate alum-borneol incorporated polyvinyl pyrrolidone nanofibers using coaxial electrospinning.
  • To investigate the in vitro release behavior and solubility enhancement of borneol within these nanofibers.

Main Methods:

  • Coaxial electrospinning of polyvinyl pyrrolidone fibers containing alum and borneol.
  • Characterization using scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and differential scanning calorimetry.
  • In vitro dissolution studies to evaluate borneol release profiles and mechanisms.

Main Results:

  • Fabricated core-shell nanofibers maintained integrated morphology.
  • In vitro dissolution demonstrated significantly improved borneol solubility, reaching over 82% at 240 minutes with a 2:1 alum to borneol ratio.
  • Borneol solubility was 4.8 times higher compared to pure borneol powder.

Conclusions:

  • Alum-borneol incorporated polyvinyl pyrrolidone nanofibers effectively enhance borneol dissolution rate.
  • This approach provides a novel strategy for the combined clinical application of alum and borneol in burn treatment.