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Update on cancer therapy-induced atherosclerosis
1Division of Oncology, Franciscan Health and Butler University College of Pharmacy and Health Sciences.
Current Opinion in Cardiology
|June 22, 2022
Summary
Cancer therapies can accelerate atherosclerosis, increasing cardiovascular risk. Early intervention with aspirin or statins may mitigate this risk, improving outcomes for cancer patients.
Area of Science:
- Oncology
- Cardiology
- Pharmacology
Background:
- Cancer therapies have improved survival but increase cardiovascular complications.
- Accelerated atherosclerosis is a key concern in cancer patients due to shared risk factors and cancer treatments.
Purpose of the Study:
- To review recent studies on anticancer agents that accelerate atherosclerosis.
- To highlight the role of specific cancer therapies in promoting atherosclerosis.
Main Methods:
- Review of recent studies on four classes of anticancer agents.
- Inclusion of radiation therapy's impact on atherosclerosis.
Main Results:
- Breakpoint cluster region-Ableson (BCR-ABL) tyrosine kinase inhibitors, immunotherapies, androgen deprivation therapies, and vascular endothelial growth factor inhibitors can accelerate atherosclerosis.
- Radiation therapy also contributes to accelerated atherosclerosis.
Conclusions:
- Mitigating common risk factors and recognizing enhanced atherosclerotic risk from oncologic therapies are crucial.
- Prophylactic use of aspirin and/or statins may improve outcomes for cancer patients exposed to these agents.
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