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Psychological interventions for inflammatory bowel disease: a systematic review and component network meta-analysis
Natalia Tiles-Sar1, Johanna Neuser2, Dominik de Sordi2
1Department of Epidemiology and Biometry, Carl von Ossietzky University of Oldenburg, Oldenburg, Germany natalia.tiles-sar@uni-oldenburg.de.
BMJ Open
|June 22, 2022
Summary
This study protocol outlines a network meta-analysis to evaluate psychological interventions for improving quality of life and clinical outcomes in inflammatory bowel diseases (IBD). It aims to address heterogeneity in previous reviews using advanced meta-analysis techniques.
Area of Science:
- Gastroenterology and Hepatology
- Psychiatry and Psychology
- Evidence Synthesis
Background:
- Patients with inflammatory bowel diseases (IBD) experience significant psychological distress, unemployment, disability, and reduced quality of life.
- Previous reviews on psychological interventions for IBD are limited by high heterogeneity in intervention designs.
- Network meta-analysis (NMA) and component network meta-analysis (CNMA) can address heterogeneity and provide more robust evidence.
Purpose of the Study:
- To systematically investigate the efficacy of psychological interventions in improving quality of life, clinical, and social outcomes for patients with IBD.
- To utilize NMA and CNMA to overcome the heterogeneity challenge in existing literature.
- To provide a comprehensive evidence synthesis for psychological interventions in IBD management.
Main Methods:
- Protocol for a systematic review and meta-analysis, including NMA and CNMA.
- Inclusion of randomized, quasi-randomized, and non-randomized controlled trials with a minimum follow-up of 2 months.
- Comprehensive literature search across multiple databases (Medline, Embase, Web of Science, etc.) and trial registries.
- Independent screening, data extraction, and quality assessment by at least two reviewers.
- Data synthesis using pairwise meta-analysis, meta-regression, NMA, and CNMA with R Package netmeta.
Main Results:
- This section is not applicable as this is a study protocol.
- Results will be reported upon completion of the planned systematic review and meta-analysis.
Conclusions:
- This study protocol outlines a rigorous approach to evaluate psychological interventions for IBD using advanced meta-analytic techniques.
- The findings are expected to clarify the effectiveness of different psychological interventions and inform clinical practice for IBD patients.
- Dissemination will include peer-reviewed publications, conference presentations, and patient-friendly reports.
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