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Advanced chronic kidney disease among UK children
Lucy Plumb1,2, Winnie Magadi3, Anna Casula3
1UK Renal Registry, UK Kidney Association, Bristol, UK lucy.plumb@bristol.ac.uk.
Archives of Disease in Childhood
|June 22, 2022
Summary
Severe chronic kidney disease (CKD) in UK children is primarily driven by those needing kidney replacement therapy (KRT). More data is needed on children with CKD before they reach kidney failure to understand the full burden.
Area of Science:
- Pediatric Nephrology
- Public Health Surveillance
- Renal Medicine
Background:
- The UK Renal Registry monitors children with kidney failure on kidney replacement therapy (KRT).
- Current data collection is limited for children with chronic kidney disease (CKD) not yet on KRT.
- Understanding the prevalence of severe CKD in children is crucial for public health initiatives.
Purpose of the Study:
- To determine the prevalence of severe chronic kidney disease (CKD) in children across the UK.
- To assess the proportion of children with severe CKD who require kidney replacement therapy (KRT).
- To highlight the need for expanded data capture on pediatric CKD.
Main Methods:
- Data was collected from all UK Paediatric Nephrology centers in March 2020.
- The study included children under 16 years old with an estimated glomerular filtration rate <30 mL/min/1.73 m² as of December 2019.
- This cross-sectional data represents the prevalence of severe CKD in the pediatric population.
Main Results:
- A total of 1031 children were identified with severe CKD.
- The majority of these children (80.7%) were already on kidney replacement therapy (KRT).
- The overall prevalence of severe CKD was 81.2 per million children.
Conclusions:
- The high prevalence of severe CKD in UK children is significantly influenced by those on long-term KRT.
- Current data underrepresents the burden of CKD in childhood as it excludes pre-failure cases.
- Expanding data collection to include earlier stages of CKD is essential for a comprehensive understanding and management of pediatric kidney disease.
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