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A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease
Published on: March 1, 2022
[Research updates: the mechanism of autophagy in inflammatory bowel disease]
Shengnan Huang1, Fangfang Li2, Dan Jin2
1Department of Immunology and Pathogenic Biology, College of Medicine, Yanbian University, Yanji 133002, China.
Abstract:
Inflammatory bowel disease (IBD) is a non-specific intestinal inflammatory disease with slow onset, varying severity and recurrence. Even though the causes of IBD are still unknown, studies have indicated that the pathogenesis of IBD is associated with multiple factors, including environment, genetics, infection and immunity. Autophagy is involved in regulating the immune response of IBD through a variety of ways such as pathogen removal, immune function, regulation of inflammatory signals, or inhibition of inflammasomes. Recent studies suggested that autophagy-related genes including ATG16L1, IRGM, and NOD2 are highly susceptible genes related to IBD, and gene deletion and mutation affect the occurrence and development of IBD. Hereby, we review the mechanism of autophagy and its related genes regulating the cytokines secretion and adjusting the immune response in IBD.
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