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Isolation and Quantification of Epstein-Barr Virus from the P3HR1 Cell Line
Published on: September 28, 2022
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Two cases of EBV infection preceding lymphoma
Jonas Saal1,2,3, Busher Aboudan4, Peter Brossart5,6
1Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology, University Medical Center Bonn (UKB), Venusberg-Campus 1, 53127, Bonn, Germany. jonas.saal@ukbonn.de.
Journal of Cancer Research and Clinical Oncology
|June 22, 2022
Summary
Epstein-Barr virus (EBV) infection can lead to lymphoma. Two cases show EBV infection progressing to overt lymphoma (Hodgkin
Area of Science:
- Oncology
- Virology
- Immunology
Background:
- Epstein-Barr virus (EBV) infection is a known risk factor for lymphoma development.
- EBV is highly prevalent, with over 90% of the global population seropositive, often remaining asymptomatic.
- EBV-associated lymphomas vary in incidence by subtype, from 10% in diffuse large B-cell lymphoma (DLBCL) to 100% in endemic Burkitt lymphoma (BL).
Observation:
- Two patients presented with localized EBV infection and reactive B-cell proliferation.
- These initial diagnoses were made before the development of overt lymphoma.
Findings:
- Both patients, initially treated for localized EBV infection and reactive B-cell proliferation with B-cell-directed therapy, subsequently developed overt lymphoma.
- One patient developed classical Hodgkin's lymphoma (cHL), while the other developed angioimmunoblastic T-cell lymphoma (AITL).
Implications:
- This case series highlights a potential, albeit rare, progression pathway from localized EBV infection to distinct lymphoma subtypes.
- The findings suggest that B-cell-directed treatments in EBV-infected individuals warrant careful monitoring for lymphomagenesis.
- Further research is needed to elucidate the mechanisms underlying EBV-associated lymphomagenesis and identify predictive markers.
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