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HLA-DRB1 Polymorphisms and Rheumatologic Manifestations in Chronic Hepatitis C

Natália Bronzatto Medolago1, Adriana Camargo Ferrasi1, Oswaldo Melo da Rocha1

  • 1Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University, Botucatu, Brazil.

Current Rheumatology Reviews
|June 23, 2022
PubMed

Insights

Human Leukocyte Antigen (HLA) polymorphisms were investigated for associations with rheumatologic manifestations (RM) in chronic hepatitis C patients. The study found no susceptibility association between HLA-DRB1 alleles and RM, suggesting distinct pathways for HCV-related RM and diffuse connective tissue disease-related RM.

Area of Science:

  • Immunogenetics
  • Hepatology
  • Rheumatology

Background:

  • Hepatitis C virus (HCV) infection is linked to rheumatologic manifestations (RM), often mimicking diffuse connective tissue diseases (DCTD).
  • Distinguishing HCV-related RM from DCTD-related RM is clinically challenging.
  • Host genetic factors, including Human Leukocyte Antigen (HLA) polymorphisms, are implicated in HCV infection, but their role in differentiating RM types is unclear.

Purpose of the Study:

  • To investigate associations between HLA-DRB1 alleles and rheumatologic manifestations in patients with chronic hepatitis C.
  • To determine if HLA-DRB1 polymorphisms can help differentiate between HCV-related RM and DCTD-related RM.

Main Methods:

  • 152 patients with chronic hepatitis C underwent rheumatologic examination.
  • HLA-DRB1 typing was performed using Polymerase Chain Reaction-Sequence Specific Oligonucleotides (PCR-SSO).

Main Results:

  • 73% of patients exhibited rheumatologic complaints not attributable to other causes.
  • The DRB1*08 allele appeared to offer protection against RM in chronic hepatitis C.
  • No significant susceptibility association was found between HLA-DRB1 alleles and RM.

Conclusions:

  • The lack of association between HLA-DRB1 and the studied RM suggests distinct pathophysiological mechanisms.
  • HCV-related RM and DCTD-related RM likely involve different biological pathways.
Abstract

Keywords:
DRB1HCVHLAPCR-SSOhepatitis Crheumatologic manifestations

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