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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Liposoluble vitamins A and E in kidney disease
Maria Helena Rojo-Trejo1, Ma Ludivina Robles-Osorio1, Ernesto Sabath2
1Nutrition School, Universidad Autónoma de Querétaro, Querétaro 76910, Mexico.
World Journal of Nephrology
|June 23, 2022
Summary
This review explores how vitamin A (retinoic acid) and vitamin E (α-tocopherol) may combat oxidative stress and inflammation in kidney disease (KD). These antioxidants show potential in managing cardiovascular risks associated with chronic kidney disease (CKD).
Area of Science:
- Nephrology
- Nutritional Science
- Cardiovascular Health
Background:
- Kidney disease (KD) is linked to heightened oxidative stress, contributing to significant cardiovascular morbidity and mortality.
- Chronic kidney disease (CKD) involves inflammation and a pro-oxidative state that accelerates disease progression by damaging podocytes.
- Vitamin A and E deficits are common in CKD patients due to anorexia, dietary restrictions, and dialysis, impacting overall health.
Purpose of the Study:
- To review the roles of retinoic acid (RA) and α-tocopherol in the context of kidney disease (KD).
- To explore the potential benefits of these liposoluble vitamins in mitigating KD-related complications.
Main Methods:
- Literature review of existing studies on retinoic acid and α-tocopherol in kidney disease.
- Analysis of findings from animal models and human clinical trials concerning these vitamins.
Main Results:
- Retinoic acid (RA) and α-tocopherol possess antioxidant, anti-inflammatory, and antiapoptotic properties.
- Evidence from animal models and some human trials suggests potential therapeutic benefits of RA and α-tocopherol in KD.
Conclusions:
- Liposoluble vitamins A and E (RA and α-tocopherol) may offer protective effects against kidney disease progression and associated cardiovascular risks.
- Further research and clinical trials are warranted to establish the efficacy and optimal use of RA and α-tocopherol in managing KD.
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