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Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
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Deficits in Acoustic Startle Reactivity and Auditory Temporal Processing after Traumatic Brain Injury.

Steven W Threlkeld1, Emma Morales Cestero1, John Marshall2

  • 1Department of Neuroscience, Regis College, Weston, Massachusetts, USA.

Neurotrauma Reports
|June 23, 2022
PubMed
Summary

Traumatic brain injury (TBI) impairs central auditory processing, affecting detection of complex sounds like gaps and sweeps. This rodent model reveals deficits paralleling human TBI sensory impairments.

Keywords:
central auditory processing deficitsmodified acoustic startletraumatic brain injury

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Area of Science:

  • Neuroscience
  • Auditory Neuroscience
  • Traumatic Brain Injury Research

Background:

  • Traumatic brain injury (TBI) causes significant neurological and financial burdens.
  • Central auditory impairments are reported in adult TBI patients, potentially affecting language.
  • Rodent models of TBI have limitations in assessing higher-order auditory processing.

Purpose of the Study:

  • To evaluate the impact of TBI on central auditory processing using a modified acoustic startle paradigm.
  • To assess auditory processing across varying stimulus complexities in a rodent TBI model.
  • To investigate deficits in detecting simple and complex auditory cues post-TBI.

Main Methods:

  • Adult rats underwent unilateral controlled cortical impact injury.
  • Auditory processing was assessed using a modified acoustic startle paradigm.
  • Stimuli included single tones, silent gaps in noise, and frequency-modulated (FM) sweeps of varying complexity.

Main Results:

  • TBI rats showed reduced acoustic startle responses across most stimuli.
  • Hearing was intact for single tones, but TBI subjects had deficits in detecting rapid gaps and FM sweeps.
  • Unlike control subjects, TBI rats did not improve gap and FM sweep detection with repeated testing.

Conclusions:

  • TBI induces both low-level and higher-order central auditory processing deficits in rodents.
  • These findings in a TBI rodent model align with sensory impairments observed in human TBI patients.
  • Modified auditory detection paradigms are valuable for studying TBI-related auditory processing deficits.