Related Experiment Video
Updated: Sep 7, 2025
Adapting Gastrointestinal Organoids for Pathogen Infection and Single Cell Sequencing under Biosafety Level 3 BSL-3 Conditions
Published on: September 10, 2021
Global research production pertaining to gastrointestinal involvement in COVID-19: A bibliometric and visualised
Sa'ed H Zyoud1, Samah W Al-Jabi1, Moyad Jamal Shahwan2
1Department of Clinical and Community Pharmacy, College of Medicine and Health Sciences, An-Najah National University, Nablus 44839, Palestine.
Insights
This study analyzed global research on gastrointestinal (GI) symptoms in COVID-19. Early pandemic research focused on GI manifestations and implications for gastroenterologists, highlighting potential fecal-oral transmission.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Public Health
Background:
- Coronavirus disease 2019 (COVID-19) is a global pandemic.
- COVID-19 can manifest with gastrointestinal (GI) symptoms like diarrhea, nausea, vomiting, and abdominal pain.
Purpose of the Study:
- To conduct a bibliometric analysis of global research on gastrointestinal involvement in COVID-19.
- To identify key research trends and influential publications in this field.
Main Methods:
- Utilized the Scopus database to identify relevant publications from 2020.
- Performed a bibliometric review using VOSviewer to analyze research trends.
Main Results:
- Identified 1267 publications on GI involvement and COVID-19.
- Research articles, letters, and reviews were the predominant document types.
- The United States was the most productive country, and Huazhong University of Science and Technology the leading institution.
- The most cited paper explored GI infection and fecal-oral transmission of COVID-19.
- Key research frontiers included GI manifestations in COVID-19 patients and implications for gastroenterologists.
Conclusions:
- GI manifestations in COVID-19 patients and the impact on gastroenterology were significant research areas.
- These topics were particularly prominent in the early stages of the COVID-19 pandemic.
Background:
Coronavirus disease 2019 (COVID-19) is a global pandemic that can cause diarrhoea, nausea/vomiting, and abdominal pain, among other gastrointestinal (GI) symptoms.
Aim:
To perform a bibliometric analysis of the global research production pertaining to GI involvement in COVID-19.
Methods:
The Scopus database was used to search the global literature on GI involvement in COVID-19 during 2020. A bibliometric review of these publications was also performed using VOSviewer.
Results:
Scopus had published 95615 documents on COVID-19 in all areas of research at the time of data collection. In total, 1267 publications on the topic of GI and COVID-19 were identified. Research articles (n = 606; 47.83%), letters (293; 23.13%), and reviews (186; 14.68%) were the most popular types of documents. The most productive countries and institutions in this field were the United States and Huazhong University of Science and Technology. The most cited paper was Xiao et al, which was published in Gastroenterology as a brief communication, with 798 citations. This paper provides evidence for GI infection of COVID-19 and its possible faecal-oral transmission route. In the term cluster analysis, there were two frontiers in this field: GI manifestations among COVID-19 patients and the implications of COVID-19 for the gastroenterologist.
Conclusion:
GI manifestations among COVID-19 patients and implications of COVID-19 for gastroenterologists were of interest, especially in the early stages of the pandemic.
Related Concept Videos
01:23Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
01:17Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
01:50What is Monogastric Digestion?
01:29Gastroesophageal Reflux Disease I: Meaning and Pathophysiology