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Updated: Sep 7, 2025

Two-photon Imaging of Cellular Dynamics in the Mouse Spinal Cord
Published on: February 22, 2015
Nuclear hormone receptors in demyelinating diseases
Rocío I Zorrilla Veloz1,2, Takese McKenzie1,3, Bridgitte E Palacios1,2,3
1Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Nuclear hormone receptors are crucial for myelin maintenance and repair in demyelinating diseases. Activating these receptors shows promise for developing new therapies to combat myelin loss.
Area of Science:
- Neuroscience
- Endocrinology
- Cell Biology
Background:
- Demyelination, the loss of myelin, is central to neurodegenerative diseases.
- Current treatments for demyelinating diseases lack myelin-repairing capabilities.
- Nuclear hormone receptors play a vital role in myelin maintenance.
Purpose of the Study:
- To review the role of nuclear hormone receptors in promoting and maintaining myelination.
- To explore the therapeutic potential of nuclear hormone receptors for demyelinating diseases.
Main Methods:
- Review of pre-clinical studies in animal models of demyelination.
- Analysis of clinical trials investigating nuclear hormone receptor ligands in multiple sclerosis (MS).
Main Results:
- Nuclear hormone receptors (estrogen, progesterone, androgen, vitamin D, thyroid hormone, PPAR, LXR, RXR) promote oligodendrocyte maturation and development.
- Ligand activation of these receptors enhances myelin protein and lipid synthesis in animal models.
- Clinical trials indicate improved outcomes in MS patients treated with certain nuclear hormone receptor ligands.
Conclusions:
- Nuclear hormone receptors are key regulators of myelination.
- Targeting nuclear hormone receptors offers a promising therapeutic strategy for demyelinating diseases like MS.
- Further clinical research is warranted to fully explore their therapeutic potential.
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