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04:57
Establishing a Competing Risk Regression Nomogram Model for Survival Data
Published on: October 23, 2020
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Stroke Outcomes in Women: A Population-Based Cohort Study.
Min Xu1, Adriana Amarilla Vallejo2, Clara Cantalapiedra Calvete1
1School of Population Health and Environmental Sciences (M.X., C.C.C., A.R., C.W., M.D.L.O., A.D.), King's College London, United Kingdom.
Stroke
|June 23, 2022
Summary
Women with stroke had better survival rates but poorer long-term outcomes in daily living and mental health compared to men, with differences lasting up to five years post-stroke.
Area of Science:
- Neurology
- Public Health
- Epidemiology
Background:
- Limited data exist on long-term sex disparities following stroke.
- This study investigates sex differences in stroke outcomes over 25 years.
Purpose of the Study:
- To estimate sex differences in long-term stroke outcomes.
- To analyze mortality, stroke recurrence, and quality of life by sex.
Main Methods:
- Prospective follow-up of 6687 stroke survivors from the South London Stroke Register.
- Kaplan-Meier curves and Cox proportional hazards models for survival and recurrence.
- Generalized estimating equations for self-reported outcomes, adjusting for confounders.
Main Results:
- Women (49%) had lower adjusted risk of death (9%) and stroke recurrence or death (6%) compared to men.
- Women experienced poorer outcomes in activities of daily living and anxiety up to 5 years post-stroke.
- Women reported lower health-related quality of life in physical and mental domains.
Conclusions:
- Female stroke survivors exhibit better adjusted survival but worse long-term functional and mental health outcomes than males.
- Sex differences in outcomes persist for up to 5 years post-stroke.
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