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Related Concept Videos

Clinical Trials: Overview01:11

Clinical Trials: Overview

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Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
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Clinical Trials01:16

Clinical Trials

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Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
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Updated: Sep 7, 2025

A Protocol for the Use of Remotely-Supervised Transcranial Direct Current Stimulation tDCS in Multiple Sclerosis MS
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Decentralised clinical trials in multiple sclerosis research.

Afagh Garjani1, Brandon Jun-Yu Liu2, Christopher Martin Allen1

  • 1Mental Health and Clinical Neurosciences Academic Unit, School of Medicine, University of Nottingham, Nottingham, UK/Academic Neurology, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Multiple Sclerosis (Houndmills, Basingstoke, England)
|June 23, 2022
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Summary
This summary is machine-generated.

Decentralised clinical trials (DCTs) leverage digital technology for remote multiple sclerosis (MS) research, enhancing participant diversity and data collection flexibility. This review examines DCT evidence and knowledge gaps in MS research.

Keywords:
Decentralisedclinical trialdigitalmultiple sclerosisrandomised controlled trialremote

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Area of Science:

  • Neurology
  • Clinical Research Methodology

Background:

  • Randomised controlled trials (RCTs) are crucial for evaluating multiple sclerosis (MS) interventions.
  • Traditional RCTs faced disruptions, particularly during the COVID-19 pandemic.
  • Digital and mobile technologies have enabled the development of decentralised clinical trials (DCTs).

Purpose of the Study:

  • To review the current evidence on the design and conduct of DCTs in MS research.
  • To identify existing knowledge gaps in the implementation of DCTs for MS.

Main Methods:

  • Review of existing literature and evidence on decentralised clinical trials in multiple sclerosis.
  • Analysis of the role of digital and mobile technologies in remote trial conduct.
  • Examination of challenges and benefits associated with DCTs in MS.

Main Results:

  • DCTs offer remote participation, increasing population heterogeneity and convenience.
  • Digital tools facilitate flexible and frequent assessments in decentralised settings.
  • The COVID-19 pandemic highlighted the need for adaptable trial methodologies like DCTs.

Conclusions:

  • DCTs represent a significant evolution in clinical trial methodology for multiple sclerosis.
  • Further research is needed to address knowledge gaps in designing and conducting MS DCTs.
  • DCTs have the potential to improve the efficiency and accessibility of MS research.