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[Guidelines on genetic testing in psychiatry: an overview].

M Z van der Horst, C M Aalfs, J A S Vorstman

Tijdschrift Voor Psychiatrie

|June 23, 2022

Summary

Genetic testing can explain psychiatric symptoms and guide treatment. Psychiatrists should consider genetic testing for patients with intellectual disability or specific warning signs like developmental delay or family history.

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Area of Science:

Psychiatry
Clinical Genetics
Medical Research

Background:

Technological advancements have identified genetic variations linked to psychiatric symptoms.
Genetic causes can explain patient/family concerns and enable targeted treatment for comorbidities.
Currently, genetic testing is underutilized in psychiatric patient care.

Purpose of the Study:

To review literature and guidelines on genetic testing in psychiatric disorders.
To offer clinical practice guidance on indications for genetic testing.

Main Methods:

Systematic search of PubMed and Embase for genetic testing recommendations in psychiatric disorders.
Analysis of national and international genetic testing guidelines in psychiatry.
Findings summarized in an infographic.

Main Results:

Referral to a clinical geneticist is recommended for patients with psychiatric disorders and intellectual disability.
Psychiatrists should consider genetic testing for other psychiatric disorders with 'red flags' (e.g., family history, congenital abnormalities, developmental delay, dysmorphic features, movement disorders, cognitive decline).
Psychiatrists can initiate genetic testing or refer patients to clinical geneticists.

Conclusions:

Genetic anomalies can underlie psychiatric disorders, especially with co-occurring somatic symptoms.
Psychiatrists must identify warning signs of genetic abnormalities and know when to pursue genetic testing.